Distinct patterns in the gut microbiota after surgical or medical therapy in obese patients

PeerJ
Daniel A MedinaDaniel Garrido

Abstract

Bariatric surgery is highly successful in improving health compared to conventional dietary treatments. It has been suggested that the gut microbiota is a relevant factor in weight loss after bariatric surgery. Considering that bariatric procedures cause different rearrangements of the digestive tract, they probably have different effects on the gut microbiota. In this study, we compared the impact of medical treatment, sleeve gastrectomy and Roux-en-Y gastric bypass on the gut microbiota from obese subjects. Anthropometric and clinical parameters were registered before, 6 and 12 months after treatment. Fecal samples were collected and microbiota composition was studied before and six months post treatment using 16S rRNA gene sequencing and qPCR. In comparison to dietary treatment, changes in intestinal microbiota were more pronounced in patients subjected to surgery, observing a bloom in Proteobacteria. Interestingly, Bacteroidetes abundance was largely different after six months of each surgical procedure. Furthermore, changes in weight and BMI, or glucose metabolism, correlated positively with changes in these two phyla in these surgical procedures. These results indicate that distinct surgical procedures alter the gut micro...Continue Reading

References

Jan 21, 2018·Obesity Surgery·Andre Alonso Taco-Masias, Augusto Rafael Fernandez-Aristi
Dec 28, 2017·Obesity Surgery·Kiminori WatanabeMasafumi Inomata
Jan 5, 2018·Diabetology & Metabolic Syndrome·Paul M RyanNoel M Caplice
Oct 18, 2018·Diabetes, Obesity & Metabolism·Patrick LeeMary B Yacyshyn
Apr 4, 2019·Nutrients·Sarah J HallbergShaminie J Athinarayanan
Jan 23, 2020·Nutrients·Daniela CiobârcăGianina Crișan
Apr 7, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Elisa Morales-MarroquinSarah E Messiah
Jul 11, 2020·Chinese Medical Journal·Li-Yuan ZhouXin-Hua Xiao
Mar 15, 2020·NPJ Biofilms and Microbiomes·Zehra Esra IlhanRosa Krajmalnik-Brown
Jul 2, 2019·The British Journal of Nutrition·Pamela ThomsonDaniel Garrido
May 25, 2020·Obesity Surgery·Naomi DaviesRinki Murphy
Aug 11, 2020·Journal of the Endocrine Society·Fatimo BiobakuParesh Dandona
May 8, 2018·Journal of Endocrinological Investigation·A Pucci, R L Batterham
Apr 15, 2019·Obesity Surgery·Josianne C H B M LuijtenMisha D P Luyer
Mar 30, 2019·Journal of Physiology and Biochemistry·María Jesús Villanueva-MillánJosé-Antonio Oteo

Citations

Nov 1, 1991·The American Journal of Clinical Nutrition·T TodescoD J Jenkins
Jul 25, 1998·Alimentary Pharmacology & Therapeutics·S I Cook, J H Sellin
Oct 14, 2004·JAMA : the Journal of the American Medical Association·Henry BuchwaldKaren Schoelles
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Jul 8, 2005·Applied and Environmental Microbiology·Noah FiererRobert B Jackson
Jul 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ruth E LeyJeffrey I Gordon
Apr 14, 2006·The British Journal of Nutrition·Takashi FushimiToshinao Goda
Jul 6, 2006·Applied and Environmental Microbiology·Todd Z DeSantisGary L Andersen
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Jun 5, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Alex EscalonaSergio Guzmán
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace
Aug 24, 2007·The New England Journal of Medicine·L SjöströmSwedish Obese Subjects Study
Sep 27, 2007·Obesity Surgery·Andrew A GumbsAlfons Pomp
Oct 1, 2008·The American Journal of Medicine·Jeffrey A TiceMitchell D Feldman
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L Sjöström
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Husen ZhangRosa Krajmalnik-Brown
Apr 29, 2009·Environmental Microbiology·Sylvia H DuncanHarry J Flint
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Jul 29, 2010·Physiological Reviews·Inna SekirovB Brett Finlay
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Carlotta De FilippoPaolo Lionetti
Jun 28, 2011·Journal of Microbiological Methods·Tristano Bacchetti De GregorisJ Grant Burgess
Jul 1, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B OhlssonG N Fredrikson
Sep 23, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S EldarPhilip R Schauer
Jun 1, 2012·Obesity Facts·John G KralBarbara J Moore
Jun 16, 2012·Nature·Human Microbiome Project Consortium
Jun 16, 2012·Nature·Tanya YatsunenkoJeffrey I Gordon
Sep 4, 2012·Current Opinion in Biotechnology·Jean Guy LeBlancMarco Ventura
Nov 13, 2012·Nucleic Acids Research·Deepak BalasubramanianKalai Mathee
Mar 29, 2013·Science Translational Medicine·Alice P LiouLee M Kaplan
Sep 26, 2013·Methods in Enzymology·José A Navas-MolinaRob Knight
Apr 1, 2014·The New England Journal of Medicine·Philip R SchauerSTAMPEDE Investigators
Oct 14, 2014·FEBS Letters·William A WaltersRob Knight
Nov 25, 2014·Cell·Julia K GoodrichRuth E Ley
Feb 25, 2015·BioMed Research International·Antje Damms-MachadoStephan C Bischoff
Jun 3, 2015·Open Forum Infectious Diseases·Neha Alang, Colleen R Kelly

Related Concepts

Real-Time Polymerase Chain Reaction
Study
Patterns
Obesity
Roux-en-Y Gastrojejunostomy
Phyla
Microbiota (Procedure)
Pharmacotherapy
Glucose Metabolism
Feces

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