Distinct patterns of IgH structure and organization in a divergent lineage of chrondrichthyan fishes

Immunogenetics
J P RastG W Litman

Abstract

Immunoglobulin heavy chain (IgH) genes in representative chondrichthyan fishes (sharks and skates) consist of independently functioning clusters, containing separate variable (VH), diversity (DH), and joining (JH) region elements and constant (CH) region exons. IgH loci have been characterized in Hydrolagus colliei (spotted ratfish), a modern representative of a major independent chondrichthyan lineage. Three distinct families of IgH gene clusters were identified. The most numerous genes consist of unjoined VH-D1-D2-JH segments that correspond to the most abundant Hydrolagus spleen (cDNA) transcripts which apparently arise from a diversified gene family. In the second cluster type, VH, DH, and JH segments are germline-joined, whereas the CH exons exhibit typical organization. This gene type is found in only a few copies per haploid genome and both transmembrane and secretory transcripts have been identified. A third cluster type has been identified that consists of unjoined VH elements but lacks a typical CH1 exon, which is substituted with a second CH2-like exon. Transcripts from this third cluster type also appear to derive from a diversified gene family. Genomic D regions of the two unjoined clone types exhibit structural di...Continue Reading

Citations

Oct 16, 2002·Developmental and Comparative Immunology·Sirje TimmuskLars Pilström
Jan 25, 2003·Developmental and Comparative Immunology·K E ConrathV K Nguyen
May 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hao ChenJohn J Marchalonis
Dec 19, 2007·The Journal of Experimental Medicine·Xiangang ZouMarianne Brüggemann
Jun 30, 2009·International Immunology·Louise S MathesonMarianne Brüggemann
Jan 23, 1999·Immunological Reviews·J J MarchalonisV S Hohman
Jan 23, 1999·Immunological Reviews·L PilströmN E Wermenstam
Jan 23, 1999·Immunological Reviews·S Bartl
Jun 8, 1999·Annual Review of Immunology·G W LitmanJ P Rast
May 11, 2004·BMC Immunology·Lynn L RumfeltMartin F Flajnik
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·L L RumfeltM F Flajnik
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·K H RouxM F Flajnik
May 20, 2014·Expert Opinion on Drug Discovery·Michael F Criscitiello
Mar 19, 2011·Developmental and Comparative Immunology·Eva-Stina EdholmMelanie Wilson
Jan 28, 2014·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Nil Ratan SahaChris T Amemiya
Sep 9, 2005·Developmental and Comparative Immunology·H Dooley, M F Flajnik
Sep 17, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sabrina OliveiraPaul M P van Bergen En Henegouwen
Sep 29, 2009·Developmental and Comparative Immunology·Hao ChenSamuel F Schluter
Jun 17, 2016·Molecular BioSystems·Asier GalánMangesh Bhide
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiangang ZouMarianne Brüggemann
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pedro GeraldesMarilia Cascalho
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ellen Hsu
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor LeeEllen Hsu
Oct 30, 2020·Frontiers in Immunology·Sabine FlickerSergei V Tillib
Oct 29, 2021·European Journal of Immunology·Kamala AnumukondaEllen Hsu

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