Distinct patterns of skeletal muscle mitochondria fusion, fission and mitophagy upon duration of exercise training

Acta Physiologica
Yoan ArribatFrancesca Amati

Abstract

Healthy ageing interventions encompass regular exercise to prevent mitochondrial dysfunction, key player in sarcopenia pathogenesis. Mitochondrial biogenesis has been well documented, but mitochondrial remodelling in response to exercise training is poorly understood. Here we investigated fusion, fission and mitophagy before and after an exercise intervention in older adults. Skeletal muscle biopsies were collected from 22 healthy sedentary men and women before and after 4 months of supervised training. Eight lifelong trained age- and gender-matched volunteers served as positive controls. Transmission electron microscopy was used to estimate mitochondrial content. Western blotting and qRT-PCR were used to detect changes in specific proteins and transcripts. After intervention, mitochondrial content increased to levels of controls. While enhancement of fusion was prevalent after intervention, inhibition of fission and increased mitophagy were dominant in controls. Similarly to PARKIN, BCL2L13 content was higher in controls. The observed molecular adaptations paralleled long-term effects of training on physical fitness, exercise efficiency and oxidative capacity. This study describes distinct patterns of molecular adaptations in ...Continue Reading

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Citations

Nov 16, 2018·Acta Physiologica·Andrea Del Campo
Apr 21, 2020·Acta Physiologica·Philipp HillmeisterIvo Buschmann
Jul 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Megan L Rexius-HallMegan L McCain
Jul 13, 2019·International Journal of Molecular Sciences·Veronica CocettaMonica Montopoli
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Dec 29, 2020·The Journal of Physiology·Ashleigh M PhilpAndrew Philp
Dec 19, 2020·Acta Physiologica·Kathrin Groeneveld
Mar 7, 2021·International Journal of Molecular Sciences·Anna S NichenkoJarrod A Call
Mar 23, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mauricio Castro-SepulvedaHermann Zbinden-Foncea
Dec 15, 2020·Medicine and Science in Sports and Exercise·Benjamin A KuglerKai Zou
Jul 3, 2021·International Journal of Molecular Sciences·Johannes BurtscherNadège Zanou
Oct 26, 2021·Exercise and Sport Sciences Reviews·Heath G GasierClaude A Piantadosi

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