Distinct phenotype and function of NK cells in the pancreas of nonobese diabetic mice

The Journal of Immunology : Official Journal of the American Association of Immunologists
Hanna BraunerPetter Höglund

Abstract

Little is known about target organ-infiltrating NK cells in type 1 diabetes and other autoimmune diseases. In this study, we identified NK cells with a unique phenotype in the pancreas of NOD mice. Pancreatic NK cells, localized to the endocrine and exocrine parts, were present before T cells during disease development and did not require T cells for their infiltration. Furthermore, NK cells, or NK cell precursors, from the spleen could traffic to the pancreas, where they displayed the pancreatic phenotype. Pancreatic NK cells from other mouse strains shared phenotypic characteristics with pancreatic NK cells from NOD mice, but displayed less surface killer cell lectin-like receptor G1, a marker for mature NK cells that have undergone proliferation, and also did not proliferate to the same extent. A subset of NOD mouse pancreatic NK cells produced IFN-gamma spontaneously, suggesting ongoing effector responses. However, most NOD mouse pancreatic NK cells were hyporesponsive compared with spleen NK cells, as reflected by diminished cytokine secretion and a lower capacity to degranulate. Interestingly, such hyporesponsiveness was not seen in pancreatic NK cells from the nonautoimmune strain C57BL/6, suggesting that this feature is...Continue Reading

References

Feb 1, 1994·Diabetes Research and Clinical Practice·R LoriniF Severi
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·I AndréD Mathis
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
Dec 31, 1997·The Journal of Experimental Medicine·B ZhangT Tabira
May 29, 1998·European Journal of Immunology·Y MatsumotoN Tanuma
Mar 23, 2001·Nature Immunology·F D ShiH G Ljunggren
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F D ShiH G Ljunggren
Jun 30, 2001·International Immunology·L D PoultonA G Baxter
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott H RobbinsLaurent Brossay
Apr 27, 2002·Scandinavian Journal of Immunology·M FlodströmH-G Ljunggren
Jan 18, 2003·Immunity·Kouetsu OgasawaraLewis L Lanier
Jul 9, 2003·The Journal of Experimental Medicine·Mohammed Javeed I AnsariMohamed H Sayegh
Oct 3, 2003·Nature Reviews. Immunology·David H Raulet
Oct 22, 2003·The Journal of Experimental Medicine·Louise A KoopmanJack L Strominger
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·I-Fang LeeRusung Tan
May 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Laurent PoirotDiane Mathis
Jun 11, 2004·Immunity·Kouetsu OgasawaraLewis L Lanier
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott H RobbinsLaurent Brossay
Nov 9, 2004·Nature Immunology·Alfonso Martín-FontechaFederica Sallusto
Dec 18, 2004·Journal of Immunological Methods·Galit AlterMarcus Altfeld
Mar 18, 2005·Annual Review of Immunology·Mark S Anderson, Jeffrey A Bluestone
Aug 25, 2005·Trends in Immunology·Sofia JohanssonPetter Höglund
Oct 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hernan D KopcowJack L Strominger
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshihiro Hayakawa, Mark J Smyth
Sep 9, 2006·Journal of Leukocyte Biology·Natacha RalainirinaJacques Zimmer
Oct 3, 2006·Nature Immunology·Christian A J VosshenrichJames P Di Santo
Nov 15, 2006·Immunological Reviews·B Anne CroyChandrakant Tayade
Dec 29, 2006·Diabetes·Melanie RodackiDiane Mathis
Feb 17, 2007·Nature Immunology·Arlene H SharpeGordon J Freeman
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Francesco DottaPiero Marchetti
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas D HuntingtonStephen L Nutt
Jan 15, 2008·Clinical and Experimental Immunology·A AlbaM Vives-Pi
Apr 22, 2008·Nature Immunology·James P Di Santo
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hakim YadiFrancesco Colucci
Jan 28, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Donald CheatemBellur S Prabhakar

❮ Previous
Next ❯

Citations

Mar 9, 2011·Immunology and Cell Biology·Eveline AngstetraHelen E Thomas
Sep 24, 2011·Nature Reviews. Immunology·Fu-Dong ShiLuc Van Kaer
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kutlu G ElpekShannon J Turley
Jul 17, 2013·Arthritis Research & Therapy·Leslie A FogelAnthony R French
May 5, 2012·PloS One·Joshua N BeilkeLewis L Lanier
Jan 21, 2011·PLoS Pathogens·Marlowe S TessmerLaurent Brossay
Aug 6, 2015·Immunology and Cell Biology·Hanna BraunerSofia Johansson
Mar 10, 2015·Journal of Neuro-oncology·Jennifer E Kim, Michael Lim
Jan 28, 2015·Nature Reviews. Endocrinology·James C Reed, Kevan C Herold
Jun 23, 2012·Diabetes·S Alice LongUNKNOWN Diabetes TrialNet and the Immune Tolerance Network
Mar 14, 2017·Journal of Autoimmunity·Cai Zhang, Zhigang Tian
Dec 9, 2017·Frontiers in Endocrinology·Allison L Bayer, Christopher A Fraker
Jun 26, 2010·Nature Reviews. Immunology·Agnès LehuenAnne Cooke
Mar 19, 2014·Journal of Cellular and Molecular Medicine·Min LiXin-Yu Qin
Mar 13, 2020·Frontiers in Immunology·Nuriban Valero-Pacheco, Aimee M Beaulieu
Sep 29, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christiane D WrannHeike Nave
Aug 19, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chamutal GurOfer Mandelboim
Jan 5, 2013·Clinical and Experimental Immunology·A E Barcala TabarrozziM J Perone
Jul 22, 2014·European Journal of Immunology·Jesper LarsenKarsten Buschard
Sep 25, 2016·Current Diabetes Reports·Chris Fraker, Allison L Bayer
Sep 11, 2016·Current Diabetes Reports·Sherman S LeungDanielle J Borg
Oct 11, 2017·Frontiers in Endocrinology·Michele L SemeraroMargaret A Morris
Jul 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huiming ShengYang D Dai
Mar 15, 2018·International Journal of Molecular Sciences·Valeria La MarcaAlessandra Fierabracci
Jul 6, 2011·Tissue Antigens·M InngjerdingenJ T Vaage
Nov 20, 2016·Clinical and Experimental Pharmacology & Physiology·Yupan ZhangYanfang Jiang
Apr 13, 2010·Seminars in Immunopathology·Fabio Arturo GriecoFrancesco Dotta
Feb 9, 2021·Clinical & Translational Immunology·Yuyan YangCynthia Louis
Feb 12, 2021·Frontiers in Immunology·Laia Gomez-MuñozMarta Vives-Pi
Mar 30, 2021·Frontiers in Immunology·Meifang LiuCai Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.