Abstract
For decades the natural history of gastroesophageal reflux disease (GERD) has been approached as spectrum-continuum, emphasizing the potential progress over time of patients along the spectrum. This commonly adopted conceptual framework had a profound impact on the field, affecting our research priorities and current management of GERD patients. A recent new conceptual framework has been proposed, suggesting that in response to factors that promote gastroesophageal reflux, patients may develop 3 distinct phenotypic presentations: non-erosive reflux disease; erosive esophagitis, and Barrett's esophagus. Most studies thus far, albeit unsatisfactory in their design, have demonstrated a very limited movement in between the 3 phenotypic presentations of GERD, further suggesting that those once determined remain true to form. The new conceptual framework emphasizes the importance of understanding symptom generation in GERD and the need to focus on the etiology and management of each phenotypic presentation of GERD. Additionally, it supports the usage of on-demand or intermittent antireflux treatment in clinical practice and provides better understanding of one of the most important clinical dilemmas - proton pump inhibitor failure.
Citations
Jun 13, 2006·Current Gastroenterology Reports·Ronnie Fass, Ram Dickman
Oct 22, 2008·Gut·Y-C LeeT H-H Chen
Jan 14, 2010·Gastroenterology Research and Practice·Theodore LiakakosEvangelos P Misiakos
Aug 4, 2010·Journal of Neurogastroenterology and Motility·Pyoung Ju SeoDong Ho Lee
Jan 19, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jeffrey P KanneJoel E Lichtenstein
Sep 1, 2007·Current Treatment Options in Gastroenterology·Tomás Navarro-Rodriguez, Ronnie Fass
Jan 24, 2007·American Journal of Surgery·Jose M Remes-TrocheSatish S C Rao
Jan 6, 2006·Alimentary Pharmacology & Therapeutics·M ShapiroR Fass
Jan 13, 2006·Gastroenterology·Anthony R HobsonQasim Aziz
Nov 17, 2012·Revista de gastroenterología de México·F M Huerta-IgaUNKNOWN el Grupo Mexicano para el Estudio de la Enfermedad por Reflujo Gastroesofágico 2011
Jun 4, 2005·Scandinavian Journal of Gastroenterology·Peter Bytzer
Mar 24, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F PaceN Vakil
Jun 9, 2006·Current Opinion in Gastroenterology·Emmanuel CoronJean-Paul Galmiche
Feb 20, 2010·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jung Hwan Oh
Jul 14, 2005·Alimentary Pharmacology & Therapeutics·R FassJ Sewell
Jul 27, 2005·Alimentary Pharmacology & Therapeutics·R Jones, J P Galmiche
Oct 28, 2016·Annals of the New York Academy of Sciences·Jung Hwan Oh
Sep 11, 2007·Digestive Diseases·Vincenzo SavarinoPietro Dulbecco
Nov 11, 2011·Alimentary Pharmacology & Therapeutics·P MalfertheinerS N Willich
Aug 21, 2013·The Annals of Otology, Rhinology, and Laryngology·Claudia A EckleyLuiz Vicente Rizzo