Distinct profile and prognostic impact of body composition changes in idiopathic pulmonary fibrosis and idiopathic pleuroparenchymal fibroelastosis

Scientific Reports
Yuzo SuzukiTakafumi Suda

Abstract

Change in body composition with skeletal muscle wasting, a major component of pulmonary cachexia, is associated with mortality in chronic obstructive pulmonary disease and cancer. However, its relevance in interstitial lung diseases (ILDs) remains unclear. We hypothesized changes in body composition would be associated with mortality in ILDs. We measured the cross-sectional-area (ESMCSA) and muscle attenuation (ESMMA) of erector-spinae muscles, as determined by CT-imaging, in patients with idiopathic pulmonary fibrosis (IPF; n = 131) and idiopathic pleuroparenchymal fibroelastosis (iPPFE; n = 43) and controls. Subsequently, implications with prognosis were evaluated. The ESMCSA of ILD patients, but not ESMMA, was significantly smaller than that in controls. Lower ESMCSA with decreased BMI were recorded in iPPFE patients versus IPF patients, whilst IPF patients had decreased ESMCSA without BMI decline. Lower ESMCSA in IPF patients were associated with poorer prognoses. Conversely, decreased ESMMA were associated with worse survival in iPPFE patients. Multivariate analyses showed that ESMCSA in IPF and ESMMA in iPPFE were independent risk factors for mortality. Distinct changes in body composition had prognostic significance amon...Continue Reading

References

May 18, 2001·Journal of Applied Physiology·B H GoodpasterA B Newman
Aug 23, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·William J EvansStefan D Anker
Jan 12, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M MuscaritoliC C Sieber
Feb 8, 2011·The Lancet Oncology·Kenneth FearonVickie E Baracos
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Oct 12, 2011·Current Opinion in Supportive and Palliative Care·David Blum, Florian Strasser
Mar 24, 2012·The European Respiratory Journal·Taryn L ReddyAndrew G Nicholson
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa MartinVickie E Baracos
Jun 26, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sally WheelwrightColin D Johnson
Sep 17, 2013·American Journal of Respiratory and Critical Care Medicine·William D TravisUNKNOWN ATS/ERS Committee on Idiopathic Interstitial Pneumonias
Mar 1, 2014·Current Respiratory Medicine Reviews·Kentaro Watanabe
Mar 7, 2014·Journal of Cachexia, Sarcopenia and Muscle·Nicole EbnerStephan von Haehling
Jul 6, 2014·The European Respiratory Journal·Matthew MaddocksNicholas S Hopkinson
Sep 23, 2014·The European Respiratory Journal·Annemie M ScholsSally J Singh
Jul 16, 2015·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN Latin American Thoracic Association
Apr 23, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Bjørg SjøblomMarit Jordhøy
Nov 30, 2016·Journal of Cachexia, Sarcopenia and Muscle·Christopher Lipina, Harinder S Hundal
Mar 28, 2017·Current Pulmonology Reports·Martina BonifaziElisabetta A Renzoni
Dec 16, 2017·The European Respiratory Journal·Merry-Lynn N McDonaldGeorge R Washko

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Citations

Aug 20, 2019·Annals of the American Thoracic Society·Felix ChuaAthol U Wells
Mar 10, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Song-I LeeJin Woo Song
Feb 24, 2020·The Korean Journal of Internal Medicine·Jae Ha LeeJin Woo Song
Sep 25, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yuzo SuzukiTakafumi Suda
Dec 10, 2020·Journal of Clinical Biochemistry and Nutrition·Ayako MatsuoShinnichiro Hayashi
Dec 4, 2020·Journal of Clinical Medicine·Takato IkedaHiroshi Ishii
Apr 4, 2021·Journal of Clinical Medicine·Haruhiko Shiiya, Masaaki Sato
Jul 17, 2021·Respiratory Medicine·Yannick Molgat-SeonJordan A Guenette
Aug 1, 2021·Respiratory Research·Yoshiaki KinoshitaHiroshi Ishii
Sep 11, 2021·Scientific Reports·Marialuisa BocchinoLuca Scalfi

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Methods Mentioned

BETA
X-ray
imaging techniques
biopsies

Software Mentioned

SPSS Statistics
iPPFE
GraphPad Prism

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