Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

Movement Disorders : Official Journal of the Movement Disorder Society
Guangwei DuXuemei Huang

Abstract

Susceptibility MRI may capture Parkinson's disease-related pathology. This study delineated longitudinal changes in different substantia nigra regions. Seventy-two PD patients and 62 controls were studied at both baseline and after 18 months with MRI. R2* and quantitative susceptibility mapping values from the substantia nigra pars compacta and substantia nigra pars reticulata were calculated. Mixed-effects models compared controls with PD or PD subgroups having different disease durations: early (<1 year), middle (<5 years, middle-stage PD), and late (>5 years, late-stage PD). Pearson's correlation assessed associations between imaging and clinical measures. At baseline, R2* and quantitative susceptibility mapping were higher in both the substantia nigra pars compacta and substantia nigra pars reticulata in all PD patients (group effect, P ≤ 0.003). Longitudinally, the substantia nigra pars compacta R2* showed a faster increase in PD compared with controls (time × group, P = 0.002), whereas quantitative susceptibility mapping did not (P = 0.668). The substantia nigra pars reticulata R2* and quantitative susceptibility mapping did not differ between PD and controls (time × group, P ≥ 0.084), although both decreased longitudinal...Continue Reading

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Citations

Nov 9, 2018·Annals of Neurology·Guangwei DuXuemei Huang
Jan 1, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Jason LangleyXiaoping Hu
May 9, 2019·The British Journal of Radiology·Eung Yeop KimJongho Lee
Jun 11, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Niels BergslandThomas Guttuso
Sep 27, 2019·CNS Drugs·Niels BergslandRobert Zivadinov
May 15, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Mechelle M LewisXuemei Huang
Jun 20, 2019·Current Neurology and Neuroscience Reports·Stéphane PrangeStéphane Thobois
Jul 28, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Patrick L HeilmanLena Brundin
Jun 18, 2020·Frontiers in Neurology·Nadya PyatigorskayaStéphane Lehéricy
Oct 13, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·David E Vaillancourt, Stéphane Lehericy
Oct 4, 2018·Current Neurology and Neuroscience Reports·Jing YangDavid E Vaillancourt
May 18, 2020·Neurology India·Pendem Saikiran, UNKNOWN Priyanka
Dec 7, 2020·European Journal of Pharmacology·Richard B MailmanXuemei Huang
Mar 11, 2021·Parkinsonism & Related Disorders·Eun-Young LeeXuemei Huang
Apr 4, 2021·Tomography : a Journal for Imaging Research·Tzu-Wei LeeHua-Shan Liu
Apr 17, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Minkyeong KimJinyoung Youn
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Jul 3, 2021·Brain Sciences·Paola FeracoRoberto Monastero
Jul 20, 2021·Journal of Parkinson's Disease·Gregory L BrownEsther M Bowie
Dec 23, 2021·Scientific Reports·Leslie C JellenXuemei Huang

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