Distinct rapid and slow phases of salt-induced hypertension in Dahl salt-sensitive rats

Journal of Hypertension
Bruce N Van VlietAllison M Leonard

Abstract

To test the hypothesis that Dahl salt-sensitive (Dahl-S) rats exhibit distinct and separable phases of salt sensitivity. Blood pressure (BP) telemetry was used to describe the detailed time course of salt-induced hypertension in Dahl-S rats and in hybrid rats derived from Dahl-S and Dahl salt-resistant strains. Switching to a high salt (4% NaCl) diet led to a biphasic increase in BP. Phase-1 reached a plateau in 4 days whereas phase-2 progressed slowly over the subsequent 5 weeks. In hybrid rats, phase-1 was present in each rat whereas phase-2 was absent in many individuals. A correlation of the amplitude of the first and second phases was of borderline significance in Dahl-S rats (P = 0.053, R2 = 0.44, n = 9) but was clearly significant in hybrid rats (P < 0.0001, R2 = 0.78, n = 22). Increases in BP were reversible following 1 week of high salt but progressively less so after 4 and 7 weeks. Estimation of the chronic pressure-natriuresis relationship suggests that phase-1 is attributable to a reduced slope of this relationship. In contrast, phase-2 corresponds with a further reduction in slope and a progressive and irreversible resetting of the relationship to higher BP levels. Two phases of salt sensitivity coexist and provide...Continue Reading

References

Jan 11, 1992·Physiological Reviews·A W Cowley
Sep 1, 1991·The American Journal of Physiology·R J Roman, M Kaldunski
Feb 1, 1990·Journal of the Autonomic Nervous System·P R HoweJ B Minson
Jun 1, 1974·Circulation·L B PageR C Moellering
Aug 1, 1983·The American Journal of Physiology·F J Gordon, A L Mark
Jan 1, 1980·Annual Review of Medicine·A C GuytonJ W DeClue
Sep 1, 1980·The American Journal of Medicine·T FujitaC S Delea
Oct 1, 1995·Nature Medicine·D DentonR Ardaillou
Jun 11, 1995·The American Journal of Physiology·L Hu, R D Manning
Oct 1, 1994·Hypertension·R E Abbott, D Schachter
Feb 1, 1993·The American Journal of Physiology·M Weinstock, M Borosh
Mar 1, 1996·Hypertension·M H Weinberger
Dec 1, 1996·The American Journal of Physiology·B N Van VlietJ P Montani
Jul 22, 1998·Journal of the Autonomic Nervous System·Q H ChenH Kosaka
Nov 24, 1999·The American Journal of Physiology·N QiS L Britton
Apr 1, 2003·The Journal of Physiology·Bruce N Van VlietJean-Pierre Montani
Apr 30, 2003·Hypertension·Shumei MengR Davis Manning
May 8, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Bing S HuangFrans H H Leenen
Mar 25, 2005·Physiological Reviews·Pierre MenetonGraham A MacGregor

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Citations

Dec 23, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B N Van Vliet, J-P Montani
Oct 18, 2006·Clinical and Experimental Pharmacology & Physiology·Bruce N Van VlietJean-Pierre Montani
Oct 31, 2009·BMC Physiology·Violeta I McLooneBruce N Van Vliet
Jun 12, 2010·Computer Methods and Programs in Biomedicine·Violeta McLooneBruce Van Vliet
Sep 9, 2015·Frontiers in Physiology·Casey Y Carmichael, Richard D Wainford
May 30, 2009·Clinical Science·Sailesh Mohan, Norm R C Campbell
Jun 6, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah-Jane GuildSimon C Malpas
Jun 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fiona D McBrydeCarolyn J Barrett
Oct 26, 2018·Physiological Reviews·Agustin Gonzalez-VicenteJeffrey L Garvin
Aug 18, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tengis S PavlovAlexander Staruschenko
Sep 24, 2019·American Journal of Physiology. Renal Physiology·John P Rapp, Michael R Garrett
Jul 19, 2019·International Journal of Molecular Sciences·Rayan Khaddaj MallatAndrew P Braun

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