PMID: 8613486Nov 1, 1995Paper

Distinct rate and patterns of human CD4+ T-cell depletion in hu-PBL-SCID mice infected with different isolates of the human immunodeficiency virus

Journal of Clinical Immunology
D E Mosier

Abstract

The most fundamental question about infection with the human immunodeficiency virus is the mechanism by which infection leads to depletion of CD4+ T lymphocytes, a critical cell type for the regulation of both cellular and humoral immunity. We have studied this issue using a unique small-animal model that is highly susceptible to infection with human immunodeficiency virus. Severe combined immune deficient mice are transplanted with human peripheral blood leukocytes to create hu-PBL-SCID mice, which maintain human T and B lymphocytes and some elements of functional immunity. The hu-PBL-SCID mice respond to human immune deficiency virus infection by the relatively rapid loss of human CD4+ T cells, while other human cells remain unaffected. In this paper, we review evidence showing that different isolates of human immunodeficiency virus-2 cause different rates of CD4+ T-cell depletion and that these rates reflect differences in local spread of infection with lymphoid organs.

References

Feb 15, 1991·Science·D E MosierS A Spector
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Cheng-MayerJ A Levy
Jul 11, 1986·Science·S GartnerM Popovic
Aug 1, 1993·Current Opinion in Immunology·R L Modlin, T B Nutman
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C GraziosiA S Fauci

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Citations

Jun 1, 1997·Molecular Medicine Today·M L Bonyhadi, H Kaneshima
Dec 28, 2017·Proceedings of the National Academy of Sciences of the United States of America·Shalley N KudalkarKaren S Anderson
Dec 1, 2005·Brain : a Journal of Neurology·M McCrossanP Simmonds

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