Distinct recruitment of the hippocampal, thalamic, and amygdalar neurons projecting to the prelimbic cortex in male and female rats during context-mediated renewal of responding to food cues

Neurobiology of Learning and Memory
Lauren C Anderson, Gorica D Petrovich

Abstract

Persistent responding to food cues may underlie the difficulty to resist palatable foods and to maintain healthy eating habits. Renewal of responding after extinction is a model of persistent food seeking that can be used to study the underlying neural mechanisms. In context-mediated renewal, a return to the context in which the initial cue-food learning occurred induces robust responding to the cues that were extinguished elsewhere. Previous work found sex differences in context-mediated renewal and in the recruitment of the ventromedial prefrontal cortex (vmPFC) during that behavior. Males exhibited renewal of responding to food cues and had higher Fos induction in the prelimbic area (PL) of the vmPFC, while females failed to exhibit renewal of responding and had lower Fos induction in the PL. The main aim of the current study was to determine key components of the PL circuitry mediating renewal. The focus was on inputs from three areas important in appetitive associative learning and contextual processing: the amygdala, ventral hippocampal formation, and the paraventricular nucleus of the thalamus. The goal was to determine whether neurons from these areas that send direct projections to the PL (identified with a retrograde ...Continue Reading

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Citations

Mar 3, 2020·Frontiers in Behavioral Neuroscience·Shaun Yon-Seng KhooNadia Chaudhri
Sep 25, 2020·Physiological Reviews·Mark E BoutonGavan P McNally
Mar 17, 2021·Neuroscience and Biobehavioral Reviews·Lucas de Oliveira Alvares, Fabricio H Do-Monte
May 15, 2021·Frontiers in Behavioral Neuroscience·Gorica D Petrovich

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