Distinct regulatory mechanism of yeast GPX2 encoding phospholipid hydroperoxide glutathione peroxidase by oxidative stress and a calcineurin/Crz1-mediated Ca2+ signaling pathway

FEBS Letters
Daisuke TsuziYoshiharu Inoue

Abstract

The GPX2 gene encodes a homologue of mammalian phospholipid hydroperoxide glutathione peroxidase in Saccharomyces cerevisiae. Previously, we have reported that the oxidative stress-induced expression of GPX2 is strictly regulated by Yap1 and Skn7 transcription factors. Here, we found that the expression of GPX2 is induced by CaCl(2) in a calcineurin (CN)/Crz1-dependent manner, and the CN-dependent response element was specified in the GPX2 promoter. Neither Yap1 nor Skn7 was required for Ca(2+)-dependent induction of GPX2, therefore, distinct regulation for the oxidative stress response and Ca(2+) signal response for GPX2 exists in yeast cells.

References

Jan 1, 1989·Annual Review of Biochemistry·P Cohen
Nov 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H Ruis, C Schüller
Apr 6, 2001·Cellular and Molecular Life Sciences : CMLS·R SugiuraT Kuno
Jul 11, 2001·The Journal of Biological Chemistry·A M Avery, S V Avery
Jun 12, 2002·The Journal of Biological Chemistry·Hiroyuki YoshimotoMartha S Cyert
Nov 20, 2002·Cell·Agnès DelaunayMichel B Toledano
Nov 19, 2003·Biochemical and Biophysical Research Communications·Martha S Cyert

❮ Previous
Next ❯

Citations

Mar 24, 2009·Eukaryotic Cell·Xin-Jian HeJan S Fassler
Dec 7, 2010·Eukaryotic Cell·Jan S Fassler, Ann H West
Oct 30, 2007·Eukaryotic Cell·Eve LenssenMartine A Collart
Feb 4, 2010·The Biochemical Journal·Yoshifumi TakatsumeYoshiharu Inoue
May 31, 2008·FEMS Microbiology Letters·Cláudio Marcos Lauer JúniorJoão Antonio Pêgas Henriques
Mar 6, 2007·Fungal Genetics and Biology : FG & B·Claude LamarreJean-Paul Latgé
Dec 26, 2016·The Science of the Total Environment·Noé Ferreira-RodríguezIsabel Pardo
Jun 19, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne-Sophie BorowiecGabriel Bidaux
Sep 1, 2004·The Journal of Biological Chemistry·Angela M AverySimon V Avery
Feb 3, 2005·Yeast
Mar 26, 2008·The Journal of Biological Chemistry·Amparo RuizJoaquín Ariño
Jan 7, 2020·Biochimica Et Biophysica Acta. General Subjects·Yun-Ying ZhaoYu Deng
Jan 8, 2008·Biochimica Et Biophysica Acta·Enrique HerreroElisa Cabiscol

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis