Abstract
A series of 12 human gliomas was established as xenografts in nude mice and used to evaluate the relationship between histology, genetic parameters, and response to alkylating agents. Eight were high-grade oligodendroglial tumors, and four were glioblastoma. They were characterized for their genetic alterations, including those considered as "early" alterations, namely loss of chromosome 1 +/- loss of chromosome 19q, TP53 mutation, and those considered as "late" alterations, namely loss of chromosome 10, loss of chromosome 9p, EGFR genomic amplification, PTEN mutation, CDKN2A homozygous deletion, and telomerase reactivation. Chemosensitivity of xenografts to four alkylating agents, temozolomide (42 mg/kg, days 1-5, p.o.), 1,3-bis(2-chloroethyl)-1-nitrosourea (5 mg/kg, day 1, i.p.), Ifosfamide (90 mg/kg, days 1-3, i.p.), and carboplatin (66 mg/kg, day 1, i.p.) was tested by administration of drugs to tumor-bearing mice. Although each tumor presented an individual response pattern, glioblastoma had a lower chemosensitivity than oligodendrogliomas, and temozolomide was the most effective drug. Deletion of 1p +/- 19q was associated with higher chemosensitivity, whereas late molecular alterations, particularly EGFR amplification, we...Continue Reading
References
Sep 1, 1990·Journal of Neurosurgery·J M Nazzaro, E A Neuwelt
Aug 1, 1987·Neurosurgery·M AmmiratiM Mikhael
May 1, 1987·Cancer·P C Burger, S B Green
Jan 1, 1995·Cancer Chemotherapy and Pharmacology·P J HoughtonJ A Houghton
May 1, 1995·Neurosurgery·P K SneedT L Phillips
Jan 1, 1995·Journal of Neuropathology and Experimental Neurology·S B HunterC D James
Sep 15, 1994·Cancer·M S BergerG E Keles
May 1, 1994·Journal of Neurosurgery·I SalmonR Kiss
Jan 1, 1994·Gastroenterology·R HamelinG Thomas
Mar 1, 1996·International Journal of Radiation Oncology, Biology, Physics·A ZhuA M El-Mahdi
Jun 21, 1996·International Journal of Cancer. Journal International Du Cancer·Y IwadateS Sakiyama
Aug 1, 1997·Cancer·K NakataniN Sakai
Oct 1, 1997·Journal of Neuro-oncology·N G RainovW Burkert
Oct 17, 1998·Journal of the National Cancer Institute·J G CairncrossD N Louis
Nov 6, 1998·Brain Pathology·E W NewcombD C Miller
Mar 30, 1999·International Journal of Cancer. Journal International Du Cancer·X P ZhouR Hamelin
Jun 8, 1999·Journal of Neuro-oncology·H MiettinenH Haapasalo
Oct 26, 1999·Journal of Neuro-oncology·F HuangY Kubota
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S SmithR B Jenkins
Oct 6, 2000·International Journal of Radiation Oncology, Biology, Physics·G S BaumanJ G Cairncross
Nov 4, 2000·International Journal of Cancer. Journal International Du Cancer·S BortolottoD Schiffer
Nov 18, 2000·Journal of Neuro-oncology·J A KrausU Schlegel
Jul 5, 2001·The American Journal of Pathology·H SasakiD N Louis
Sep 15, 2001·Journal of Neuropathology and Experimental Neurology·J HeK Hoang-Xuan
Oct 10, 2001·Neurology·K Hoang-XuanM Sanson
Feb 8, 2002·The New England Journal of Medicine·Ian F PollackUNKNOWN Children's Cancer Group
Jul 19, 2002·Cancer·Shoji ShiraishiYukitaka Ushio
Jun 11, 2003·Neurology·P LeuraudM Sanson
Dec 17, 2003·British Journal of Cancer·P LeuraudM Sanson
Citations
Aug 19, 2007·Cancer Chemotherapy and Pharmacology·Michael D PradosJohn Kuhn
Nov 18, 2008·Journal of Neuro-oncology·Gaspar J KitangeJann N Sarkaria
Aug 29, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B MarkmanJ Baselga
Jan 1, 2005·Current Opinion in Oncology·Marc SansonKhê Hoang-Xuan
Sep 1, 2007·Anti-cancer Drugs·Riccardo SoffiettiElisa Trevisan
Mar 15, 2014·BMC Cancer·Ivan BiecheVirginie Dangles-Marie
Apr 3, 2008·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Ingeborg FischerKenneth Aldape
Oct 26, 2010·Expert Opinion on Drug Metabolism & Toxicology·Jaishri Blakeley, Jana Portnow
May 3, 2014·Drug Delivery·Neil U BaruaSteven S Gill
Oct 12, 2011·Contemporary Clinical Trials·Jacques MedioniJean-Louis Golmard
Sep 22, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Grace Y KimMichael J Cima
Jan 26, 2010·International Journal of Cancer. Journal International Du Cancer·Eva MartinkovaMonique Dontenwill
Mar 8, 2007·British Journal of Cancer·S Spiegl-KreineckerW Berger
Mar 23, 2018·Cancer Biology & Therapy·Jing-Nan WangJie He
Feb 7, 2008·Journal of Neuro-oncology·Yuxia MengAntoine F Carpentier
Mar 14, 2018·Journal of Experimental & Clinical Cancer Research : CR·Xiao FuTao Tian
May 18, 2012·Cancer Research·Hana JanouskovaMonique Dontenwill
May 14, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-Sébastien GuillamoMarc Peschanski