Distinct retrosplenial cortex cell populations and their spike dynamics during ketamine-induced unconscious state

PloS One
Grace E FoxJoe Z Tsien

Abstract

Ketamine is known to induce psychotic-like symptoms, including delirium and visual hallucinations. It also causes neuronal damage and cell death in the retrosplenial cortex (RSC), an area that is thought to be a part of high visual cortical pathways and at least partially responsible for ketamine's psychotomimetic activities. However, the basic physiological properties of RSC cells as well as their response to ketamine in vivo remained largely unexplored. Here, we combine a computational method, the Inter-Spike Interval Classification Analysis (ISICA), and in vivo recordings to uncover and profile excitatory cell subtypes within layers 2&3 and 5&6 of the RSC in mice within both conscious, sleep, and ketamine-induced unconscious states. We demonstrate two distinct excitatory principal cell sub-populations, namely, high-bursting excitatory principal cells and low-bursting excitatory principal cells, within layers 2&3, and show that this classification is robust over the conscious states, namely quiet awake, and natural unconscious sleep periods. Similarly, we provide evidence of high-bursting and low-bursting excitatory principal cell sub-populations within layers 5&6 that remained distinct during quiet awake and sleep states. We...Continue Reading

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Citations

Jun 6, 2018·Frontiers in Systems Neuroscience·Xiaojian LiGordon M G Shepherd
Apr 25, 2018·Cerebral Cortex·Meng LiJoe Z Tsien

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Methods Mentioned

BETA
feature extraction

Software Mentioned

MATLAB
pdist
ISICA

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