Distinct roles of central and peripheral prostaglandin E2 and EP subtypes in blood pressure regulation.

American Journal of Hypertension
Tianxin Yang, Yaomin Du

Abstract

Prostaglandin E(2) (PGE(2)) is a major prostanoid with a wide variety of biological activities. PGE(2) can influence blood pressure (BP) both positively and negatively. In particular, centrally administered PGE(2) induces hypertension whereas systemic administration of PGE(2) produces a hypotensive effect. These physiologically opposing effects are generated by the existence of multiple EP receptors, namely EP(1-4), which are G protein-coupled receptors with distinct signaling properties. This review highlights the distinct roles of PGE(2) in BP regulation and the involvement of specific EP receptor subtypes.

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Citations

Sep 1, 2015·Journal of the American Society of Nephrology : JASN·Rania NasrallahRichard L Hébert
Dec 18, 2015·Journal of Receptor and Signal Transduction Research·Hai-Hua DingWei Wei
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Nov 26, 2021·Biochemical Pharmacology·Timothy D Bryson, Pamela Harding

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