Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats

The Journal of Pharmacology and Experimental Therapeutics
Shao-Rui Chen, Hui-Lin Pan

Abstract

Increased glutamatergic input to spinal dorsal horn neurons constitutes an important mechanism for neuropathic pain. However, the role of group III metabotropic glutamate receptors (mGluRs) in regulation of nociception and dorsal horn neurons in normal and neuropathic pain conditions is not fully known. In this study, we determined the effect of the group III mGluR specific agonist L(+)-2-amino-4-phosphonobutyric acid (L-AP4) on nociception and dorsal horn projection neurons in normal rats and a rat model of neuropathic pain. Tactile allodynia was induced by ligation of L5/L6 left spinal nerves in rats. Allodynia was determined by von Frey filaments in nerve-injured rats. The nociceptive threshold was tested using a radiant heat and a Randall-Selitto pressure device in normal rats. Single-unit activity of ascending dorsal horn neurons was recorded from the lumbar spinal cord in anesthetized rats. An intrathecal (5-30 microg) L-AP4 dose-dependently attenuated allodynia in nerve-injured rats but had no antinociceptive effect in normal rats. Topical spinal application of 5 to 50 microM L-AP4 also significantly inhibited the evoked responses of ascending dorsal horn neurons in nerve-ligated but not normal rats. Furthermore, blockad...Continue Reading

References

Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Sep 1, 1996·Neuroscience·J A HarrisM Bentivoglio
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·P J Conn, J P Pin
Jun 17, 1999·Lancet·C J Woolf, R J Mannion
Oct 26, 1999·Neuropharmacology·D D SchoeppJ A Monn
Jan 24, 2002·The Journal of Pharmacology and Experimental Therapeutics·Shao-Rui ChenHui-Lin Pan
May 31, 2002·Journal of Neurophysiology·Shao-Rui Chen, Hui-Lin Pan

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Citations

Feb 22, 2014·Journal of Neural Transmission·Clare Finlay, Susan Duty
Sep 24, 2005·Basic & Clinical Pharmacology & Toxicology·Andreas RitzénChristian Thomsen
Dec 17, 2014·Current Opinion in Pharmacology·Francine Acher, Cyril Goudet
Jan 17, 2009·Brain Research Reviews·Cyril GoudetJean-Philippe Pin
Dec 19, 2013·Nature Communications·Maïly DevilliersAlain Eschalier
Oct 1, 2008·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Chul Hyun Cho, Hong Kee Shin
Feb 3, 2019·The Journal of Biological Chemistry·Zack ZurawskiHeidi E Hamm
Sep 25, 2012·Experimental Physiology·Maria OsikowiczBarbara Przewlocka
Feb 6, 2014·The European Journal of Neuroscience·Enza PalazzoSabatino Maione
Sep 14, 2013·The Journal of Pharmacology and Experimental Therapeutics·Shao-Rui ChenHui-Lin Pan
Jul 2, 2016·Journal of Neurochemistry·Enza PalazzoSabatino Maione
Jan 22, 2019·Frontiers in Molecular Neuroscience·Vanessa Pereira, Cyril Goudet
Feb 6, 2018·Journal of Medicinal Chemistry·Chelliah SelvamFrancine C Acher
Oct 26, 2007·Pharmacology & Therapeutics·Hui-Lin PanDe-Pei Li

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