Distinct roles of hand2 in developing and adult autonomic neurons

Developmental Neurobiology
Sabine StanzelKonstantina Tsarovina

Abstract

The bHLH transcription factor Hand2 is essential for the acquisition and maintenance of noradrenergic properties of embryonic sympathetic neurons and controls neuroblast proliferation. Hand2 is also expressed in embryonic and postnatal parasympathetic ganglia and remains expressed in sympathetic neurons up to the adult stage. Here, we address its function in developing parasympathetic and adult sympathetic neurons. We conditionally deleted Hand2 in the parasympathetic sphenopalatine ganglion by crossing a line of floxed Hand2 mice with DbhiCre transgenic mice, taking advantage of the transient Dbh expression in parasympathetic ganglia. Hand2 elimination does not affect Dbh expression and sphenopalatine ganglion size at E12.5 and E16.5, in contrast to sympathetic ganglia. These findings demonstrate different functions for Hand2 in the parasympathetic and sympathetic lineage. Our previous Hand2 knockdown in postmitotic, differentiated chick sympathetic neurons resulted in decreased expression of noradrenergic marker genes but it was unclear whether Hand2 is required for maintaining noradrenergic neuron identity in adult animals. We now show that Hand2 elimination in adult Dbh-expressing sympathetic neurons does not decrease the e...Continue Reading

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Citations

Oct 27, 2017·Wiley Interdisciplinary Reviews. Developmental Biology·Evan Deneris, Patricia Gaspar
Jul 30, 2019·Journal of Dental Research·T H N TeshimaS V Lourenço
Sep 16, 2020·Cell and Tissue Research·Uwe ErnsbergerHermann Rohrer
Dec 2, 2020·Journal of Cachexia, Sarcopenia and Muscle·Anna Carolina Zaia RodriguesOsvaldo Delbono
Feb 22, 2021·Ageing Research Reviews·Osvaldo DelbonoMaria Laura Messi
May 4, 2021·Biological Psychiatry·Ryan W LoganMarianne L Seney
Sep 22, 2021·Journal of Cachexia, Sarcopenia and Muscle·Anna Carolina Zaia RodriguesOsvaldo Delbono

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