Distinct roles of medial and lateral entorhinal cortex in spatial cognition

Cerebral Cortex
Tiffany Van CauterEtienne Save

Abstract

It is known that the entorhinal cortex plays a crucial role in spatial cognition in rodents. Neuroanatomical and electrophysiological data suggest that there is a functional distinction between 2 subregions within the entorhinal cortex, the medial entorhinal cortex (MEC), and the lateral entorhinal cortex (LEC). Rats with MEC or LEC lesions were trained in 2 navigation tasks requiring allothetic (water maze task) or idiothetic (path integration) information processing and 2-object exploration tasks allowing testing of spatial and nonspatial processing of intramaze objects. MEC lesions mildly affected place navigation in the water maze and produced a path integration deficit. They also altered the processing of spatial information in both exploration tasks while sparing the processing of nonspatial information. LEC lesions did not affect navigation abilities in both the water maze and the path integration tasks. They altered spatial and nonspatial processing in the object exploration task but not in the one-trial recognition task. Overall, these results indicate that the MEC is important for spatial processing and path integration. The LEC has some influence on both spatial and nonspatial processes, suggesting that the 2 kinds o...Continue Reading

References

Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
May 1, 1985·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·S Millar
Aug 14, 1998·The Journal of Comparative Neurology·C L Dolorfo, D G Amaral
May 20, 2000·Annals of the New York Academy of Sciences·G C Román
Jul 27, 2000·Annals of the New York Academy of Sciences·R D Burwell
Aug 18, 2001·Behavioral Neuroscience·T J BusseyJ P Aggleton
Jun 7, 2003·Brain Research. Brain Research Reviews·Terence V Sewards, Mark A Sewards
Apr 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca D BurwellKjesten A Wiig
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Boyer D WintersTimothy J Bussey
Aug 31, 2004·Science·Marianne FyhnMay-Britt Moser
Nov 5, 2004·Experimental Brain Research·Carole Parron, Etienne Save
Feb 25, 2005·Behavioral Neuroscience·Inah LeeRaymond P Kesner
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
Jul 22, 2006·Nature Reviews. Neuroscience·Bruce L McNaughtonMay-Britt Moser
Aug 3, 2006·Learning & Memory·James J Knierim
Oct 31, 2006·Trends in Neurosciences·Menno P Witter, Edvard I Moser
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gareth R I BarkerE Clea Warburton
Sep 4, 2007·Progress in Brain Research·Menno P Witter
Apr 17, 2008·The European Journal of Neuroscience·Tiffany Van CauterEtienne Save
Apr 29, 2008·Neurobiology of Learning and Memory·Tiffany Van CauterEtienne Save
Dec 20, 2008·Science·Trygve SolstadEdvard I Moser
Mar 21, 2009·Nature Reviews. Neuroscience·N M van StrienM P Witter
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong Sang Jo, Inah Lee
Aug 5, 2010·Learning & Memory·Mathieu M AlbasserJohn P Aggleton
Sep 18, 2010·Hippocampus·Malcolm W BrownJohn P Aggleton

❮ Previous
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Citations

Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·James J KnierimSachin S Deshmukh
May 31, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joshua P NeunuebelJames J Knierim
May 8, 2013·Behavioural Brain Research·Magdalena M SauvageZachery Beer
Mar 19, 2013·Neural Networks : the Official Journal of the International Neural Network Society·J HirelB Poucet
Jul 15, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tatiana V LipinaAnn Marie Craig
Dec 5, 2015·Frontiers in Human Neuroscience·Heidrun SchultzJan Peters
Oct 21, 2015·Frontiers in Neuroscience·Barbara FerryMonique Majchrzak
Feb 3, 2015·The Journal of Comparative Neurology·Mathias L MathiasenMenno P Witter
Aug 8, 2015·Neuron·Daniel BushNeil Burgess
Jul 16, 2014·Behavioural Brain Research·Coralie Elduayen, Etienne Save
May 21, 2014·Neuroscience Letters·Yu ZhangMing Yi
Jan 12, 2013·Neuroscience·G A ReidS Darvesh
Sep 7, 2014·Behavioural Brain Research·Israela BalderasFederico Bermudez-Rattoni
Aug 26, 2014·Neurobiology of Learning and Memory·Mark D Morrissey, Kaori Takehara-Nishiuchi
Jun 14, 2014·Frontiers in Integrative Neuroscience·Pierre-Yves JacobFrancesca Sargolini
Aug 26, 2014·Frontiers in Systems Neuroscience·Panagiotis C Petrantonakis, Panayiota Poirazi
Sep 16, 2014·Frontiers in Behavioral Neuroscience·Kally C O'ReillyJanina Ferbinteanu
Oct 26, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rosaline V WaworuntuBrian M Berg
Nov 12, 2016·Frontiers in Systems Neuroscience·Alexandra S KleinPrateep Beed
Nov 27, 2015·The Journal of Physiology·Talfan EvansNeil Burgess
Mar 29, 2014·Journal of Cognitive Neuroscience·Sjoerd J H EbischVittorio Gallese
Apr 7, 2017·Neurobiology of Learning and Memory·Owen Y ChaoMaria A de Souza Silva
Jan 21, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Feifei GeXiaowei Sun
Oct 27, 2017·Nature Neuroscience·Charles E Connor, James J Knierim
Feb 8, 2013·Hippocampus·David I G WilsonJames A Ainge
Dec 13, 2017·Nature Neuroscience·Mariana GilHannah Monyer

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