Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions

Blood
Carole A OskeritzianSarah Spiegel

Abstract

Sphingosine-1-phosphate (S1P) is now emerging as a potent lipid mediator produced by mast cells that contributes to inflammatory and allergic responses. In contrast to its weak effect on degranulation of murine mast cells, S1P potently induced degranulation of the human LAD2 mast-cell line and cord blood-derived human mast cells (hMCs). S1P also stimulated production and secretion of cytokines, TNF-alpha and IL-6, and markedly enhanced secretion of a chemokine, CCL2/MCP-1, important modulators of inflammation. S1P is produced in mast cells by the 2 sphingosine kinases, SphK1 and SphK2. SphK1 but not SphK2 plays a critical role in IgE/Ag-induced degranulation, migration toward antigen, and CCL2 secretion from hMCs, as determined by specifically down-regulating their expression. However, both isoenzymes were required for efficient TNF-alpha secretion. Taken together, our data suggest that differential formation of S1P by SphK1 and SphK2 has distinct and important actions in hMCs.

References

Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·H OchiJ A Boyce
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A J AmmitR A Panettieri
Feb 22, 2002·The Journal of Biological Chemistry·Alirio J Melendez, Aik Kia Khaw
May 31, 2002·The New England Journal of Medicine·Christopher E BrightlingIan D Pavord
Oct 3, 2002·Nature Reviews. Immunology·Toshiaki Kawakami, Stephen J Galli
May 3, 2003·Nature Reviews. Molecular Cell Biology·Sarah Spiegel, Sheldon Milstien
Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Carole A OskeritzianLawrence B Schwartz
Jun 14, 2005·The Journal of Biological Chemistry·Nitai C HaitSarah Spiegel
Jun 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yasuhiro GonHugh Rosen
Oct 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patrick A SingletonJoe G N Garcia
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Debby A Lin, Joshua A Boyce
Nov 9, 2005·Journal of Leukocyte Biology·Takayuki NakayamaGiovanna Tosato
Dec 13, 2005·The Journal of Allergy and Clinical Immunology·Kentaro MatsudaStephen J Galli
Jan 13, 2006·Trends in Molecular Medicine·Shannon E GardellJerold Chun
Oct 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Poulami MitraSarah Spiegel
May 4, 2007·Current Opinion in Pharmacology·Mike BerryAj Wardlaw
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yosuke KurashimaHiroshi Kiyono

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Citations

Sep 27, 2012·Rheumatology International·DeAnna A BakerGary S Gilkeson
Sep 13, 2008·Nature Reviews. Immunology·Juan RiveraAna Olivera
May 7, 2011·Nature Reviews. Immunology·Sarah Spiegel, Sheldon Milstien
Feb 22, 2011·The Journal of Biological Chemistry·Russell W JenkinsYusuf A Hannun
Jul 30, 2011·The Journal of Biological Chemistry·Lawren C Wu
Mar 3, 2010·The Journal of Experimental Medicine·Carole A OskeritzianSarah Spiegel
Jun 19, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Megan M PriceSarah Spiegel
Aug 30, 2008·American Journal of Respiratory and Critical Care Medicine·Stefan Uhlig, Erich Gulbins
Nov 7, 2008·Journal of Lipid Research·Michael MaceykaSarah Spiegel
Feb 11, 2012·Critical Reviews in Immunology·Alasdair M Gilfillan, Michael A Beaven
Aug 30, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Yoshimichi OkayamaChisei Ra
Oct 6, 2009·Future Lipidology·Megan M PriceSarah Spiegel
Dec 3, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia-Hui ChuXian-Jun Qu
Jul 27, 2014·Current Opinion in Pharmacology·Francesco BorrielloGianni Marone
May 5, 2012·International Archives of Allergy and Immunology·Bodi ZhangTheoharis C Theoharides
Jul 18, 2012·Biochimica Et Biophysica Acta·Huasheng Chan, Stuart M Pitson
Jul 4, 2012·Trends in Pharmacological Sciences·Donald W MacGlashan
Jan 7, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lan ZhangYanmei Ma
Apr 26, 2011·Trends in Molecular Medicine·Susan Pyne, Nigel J Pyne
Sep 28, 2010·Trends in Biochemical Sciences·Stuart M Pitson
Sep 30, 2008·Current Opinion in Immunology·Donald MacGlashan
Oct 24, 2015·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Piper WedmanCarole A Oskeritzian
Apr 12, 2008·Prostaglandins & Other Lipid Mediators·Ana Olivera
Dec 3, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wei LiuLi Cai
May 29, 2012·Reviews in Medical Virology·Jillian M CarrStuart M Pitson
May 4, 2013·The FEBS Journal·Heidi A Neubauer, Stuart M Pitson
Mar 26, 2013·British Journal of Haematology·Craig T Wallington-BeddoeLinda J Bendall
Jul 15, 2015·European Journal of Pharmacology·Yingxin YuFrank A Redegeld
May 6, 2015·European Journal of Pharmacology·Petr DraberToshiaki Kawakami
Nov 26, 2010·Bioscience Reports·Wen-Qi LaiBernard P Leung
Aug 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Erlin SunRuifa Han
Apr 29, 2014·The Journal of Allergy and Clinical Immunology·Ilkka T HarvimaMarcus Maurer

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