PMID: 9645367Jun 30, 1998Paper

Distinct roles of the interleukin-7 receptor alpha chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor alpha-deficient mice

European Journal of Immunology
T CromptonM J Owen

Abstract

Mouse mutants lacking expression of the IL-7 receptor (IL-7R) alpha chain are defective in thymopoiesis. The adult thymus has multiple defects, including reduced cell numbers and proportions of the more mature thymocyte subsets, a complete absence of CD25+ cells and a reduced level of RAG1 and RAG2 expression. We show here that, in contrast to the profound developmental arrest observed in the adult thymus, fetal thymocytes from IL-7Ralpha-/- mice have normal proportions of all of the major thymocyte subpopulations, including CD25+ thymocytes and the most mature single-positive subsets. Moreover, normal levels of RAG1 and RAG2 were observed. Total thymocyte numbers, however, remained reduced. These data suggest that the IL-7Ralpha chain is a key regulator of both survival and proliferation during thymocyte development but that it is not essential for the production of T cells during fetal thymopoiesis.

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Citations

Mar 13, 2002·Developmental and Comparative Immunology·Dominick DeLuca, Dawn R Clark
Dec 30, 2009·The Journal of Experimental Medicine·Michelle L JanasMartin Turner
Oct 9, 2002·Immunological Reviews·Ellen V Rothenberg, Christopher J Dionne
Oct 9, 2002·Immunological Reviews·Paul W KincadeMaria Isabel D Rossi
Jul 10, 2004·Immunological Reviews·Dipanjan Chowdhury, Ranjan Sen
Feb 2, 2006·Immunological Reviews·Elizabeth-Sharon David-FungEllen V Rothenberg
Feb 2, 2006·Immunological Reviews·Graham AndersonEric J Jenkinson
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J J OwenE J Jenkinson
Oct 8, 2004·Developmental Cell·Kay L MedinaHarinder Singh
Mar 17, 2005·European Journal of Immunology·Gina BalciunaiteAntonius G Rolink
Aug 10, 2006·European Journal of Immunology·Siyuan LiangAnatolij Horuzsko
Jul 23, 2009·Journal of Internal Medicine·C M CapitiniC L Mackall
Nov 5, 2002·Nature Reviews. Immunology·Rod Ceredig, Ton Rolink
May 16, 2002·Blood·Terry J Fry, Crystal L Mackall
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joy A PhillipsMarilyn L Thoman
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·David B KlugEllen R Richie
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Becky Adkins
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M BairdL J Berg
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jiaxue HuangPaul W Kincade
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monica ZamischEllen R Richie
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Justin Van De WieleT Kent Teague
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K J HareG Anderson
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joonsoo KangCynthia A Chambers
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen LakyLynn Puddington
Feb 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Encarnacion Montecino-RodriguezKenneth Dorshkind
Nov 21, 2000·Seminars in Immunology·S Prockop, H T Petrie

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