Abstract
Patients with hyperplastic polyposis coli syndrome are thought to harbor precursor lesions of a proposed hyperplasia-carcinoma pathway in colorectal cancer, but morphologic recognition of such lesions remains difficult. Hypermethylation of the secreted Frizzled receptor protein 1 gene on chromosome 8p12 is one of the earliest molecular alterations in colorectal carcinogenesis, potentially disrupting the Wnt signaling cascade of cellular growth control. To determine if hyperplastic polyps from patients with hyperplastic polyposis coli syndrome show a distinct immunohistochemical expression pattern for mismatch repair proteins and secreted Frizzled receptor protein 1 compared to their sporadic counterparts. Immunohistochemical studies (secreted Frizzled receptor protein 1, 3 mismatch repair proteins, and p53) were performed on 23 hyperplastic polyps, 6 synchronous colon cancers, and normal colonic mucosa from 6 patients with hyperplastic polyposis coli syndrome and were compared with studies of sporadic hyperplastic polyps obtained from 13 matched control subjects. The staining pattern for the mismatch repair proteins MLH-1, MSH-2, and MSH-6 did not differ between sporadic and syndromic hyperplastic polyps. In contrast, 52% of sy...Continue Reading
References
Mar 1, 1996·Gastroenterology·E Torlakovic, D C Snover
Jul 1, 1996·Genes, Chromosomes & Cancer·M L YaremkoC A Westbrook
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·P W FinchJ S Rubin
Oct 10, 1997·Gastroenterology·P Peltomäki, H F Vasen
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·H S MelkonyanS R Umansky
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M Seiki
May 29, 1999·The Journal of Biological Chemistry·A BaficoS A Aaronson
Feb 8, 2000·The Journal of Biological Chemistry·A UrenJ S Rubin
Jun 22, 2000·Gut·J R JassB A Leggett
Aug 10, 2000·Gastroenterology·A RashidS R Hamilton
Aug 10, 2000·The American Journal of Pathology·N J HawkinsR L Ward
Sep 15, 2000·Human Pathology·Y ImanishiH Sato
Feb 13, 2002·The American Journal of Pathology·Annie On-On ChanAsif Rashid
Feb 21, 2002·Cancer Investigation·Annegret Müller, Richard Fishel
May 7, 2002·Nature Genetics·Hiromu SuzukiStephen B Baylin
Jul 12, 2002·Virchows Archiv : an International Journal of Pathology·Thomas BrabletzThomas Kirchner
Aug 3, 2002·Oncogene·Manel Esteller
Dec 28, 2002·The American Journal of Surgical Pathology·Emina TorlakovicJahn M Nesland
Feb 12, 2004·Cancer Research·Germaine M CaldwellDion G Morton
Feb 18, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Robert StoehrArndt Hartmann
Mar 23, 2004·Nature Genetics·Hiromu SuzukiStephen B Baylin
Citations
Mar 9, 2006·British Journal of Cancer·G M CaldwellD G Morton
Aug 2, 2007·The American Journal of Surgical Pathology·Rhonda K YantissRobert D Odze
Dec 7, 2007·The American Journal of Surgical Pathology·Rhonda K YantissYao-Tseng Chen