Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst.

Development
Berenika PlusaA K Hadjantonakis

Abstract

The first two lineages to differentiate from a pluripotent cell population during mammalian development are the extraembryonic trophectoderm (TE) and the primitive endoderm (PrE). Whereas the mechanisms of TE specification have been extensively studied, segregation of PrE and the pluripotent epiblast (EPI) has received comparatively little attention. A current model of PrE specification suggests PrE precursors exhibit an apparently random distribution within the inner cell mass of the early blastocyst and then segregate to their final position lining the cavity by the late blastocyst. We have identified platelet-derived growth factor receptor alpha (Pdgfralpha) as an early-expressed protein that is also a marker of the later PrE lineage. By combining live imaging of embryos expressing a histone H2B-GFP fusion protein reporter under the control of Pdgfra regulatory elements with the analysis of lineage-specific markers, we investigated the events leading to PrE and EPI lineage segregation in the mouse, and correlated our findings using an embryo staging system based on total cell number. Before blastocyst formation, lineage-specific factors are expressed in an overlapping manner. Subsequently, a gradual progression towards a mut...Continue Reading

References

Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G R Martin, M J Evans
Mar 1, 1992·Mechanisms of Development·S BeckerL Grabel
Jan 5, 2002·Differentiation; Research in Biological Diversity·P Murray, D Edgar
May 16, 2003·Molecular and Cellular Biology·T Guy HamiltonPhilippe Soriano
Sep 4, 2003·Development·Renée V Hoch, Philippe Soriano
Sep 27, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Janet RossantYojiro Yamanaka
Dec 28, 2004·BMC Biotechnology·Anna-Katerina Hadjantonakis, Virginia E Papaioannou
Mar 18, 2005·Nature·Berenika PlusaMagdalena Zernicka-Goetz
Dec 22, 2005·Nature Reviews. Genetics·Alfonso Martinez Arias, Penelope Hayward
Jun 15, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yojiro YamanakaJanet Rossant
Aug 16, 2006·Molecular and Cellular Biology·Takashi HamazakiNaohiro Terada
Jul 7, 2007·Stem Cells·Amar M SinghNaohiro Terada
Aug 21, 2007·BMC Developmental Biology·Aitana Perea-GomezMagdalena Zernicka-Goetz
Nov 6, 2007·Development·Jens-Erik Dietrich, Takashi Hiiragi
Dec 22, 2007·Nature·Ian ChambersAustin Smith
May 17, 2008·Genes & Development·Johanna AndraeChrister Betsholtz

❮ Previous
Next ❯

Citations

Nov 22, 2011·Analytical and Bioanalytical Chemistry·Maha A El-HagrasyEiichi Tamiya
Oct 9, 2012·Cell Reports·Samantha A MorrisMagdalena Zernicka-Goetz
Jan 9, 2009·Nature Reviews. Molecular Cell Biology·Sebastian J Arnold, Elizabeth J Robertson
Jun 20, 2013·Nature Reviews. Molecular Cell Biology·Sebastian WennekampTakashi Hiiragi
Dec 25, 2010·Nature Structural & Molecular Biology·Ziyang MaJoanna Wysocka
Jan 1, 2009·Médecine sciences : M/S·Claire Chazaud
Jun 16, 2012·Reproduction, Fertility, and Development·Muriel FilliersLuc J Peelman
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Samantha A MorrisMagdalena Zernicka-Goetz
Apr 12, 2012·Molecular & Cellular Proteomics : MCP·Rebekah L GundryKenneth R Boheler
Dec 31, 2008·Stem Cells and Development·Diego S VieyraMargaret A Goodell
Jun 2, 2009·Stem Cells and Development·Vasiliy GalatPhilip Iannaccone
May 23, 2012·Stem Cells and Development·Jason T K Hwang, Gregory M Kelly
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sui Huang
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Robert R Kay, Christopher R L Thompson
Jun 21, 2012·Genes & Development·Fabrice LavialVéronique Azuara
May 9, 2013·Genes & Development·Sonja NowotschinAnna-Katerina Hadjantonakis
Apr 7, 2010·The Journal of Clinical Investigation·Katie Cockburn, Janet Rossant
Jun 18, 2010·Development·Laurie A WyngaardenSevan Hopyan
Sep 10, 2010·Development·Jérôme ArtusAnna-Katerina Hadjantonakis
Oct 29, 2010·Development·Suh-Chin J LinJames M Wells
Feb 10, 2012·Development·Kathy K NiakanRenee A Reijo Pera
May 25, 2011·The Journal of Reproduction and Development·Hanako BaiKazuhiko Imakawa
Nov 23, 2012·The Journal of Reproduction and Development·Jared M CampbellMark B Nottle
May 17, 2011·PLoS Computational Biology·Pawel KrupinskiCarsten Peterson
Aug 17, 2010·PloS One·Kemar BrownAnn Foley
Nov 26, 2010·PloS One·Maria KeramariSusan J Kimber

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis