Distinct signaling and transcriptional pathways regulate peri-weaning development and cold-induced recruitment of beige adipocytes

Proceedings of the National Academy of Sciences of the United States of America
Yixuan WuAjay Chawla

Abstract

Adipose tissue provides a defense against starvation and environmental cold. These dichotomous functions are performed by three distinct cell types: energy-storing white adipocytes, and thermogenic beige and brown adipocytes. Previous studies have demonstrated that exposure to environmental cold stimulates the recruitment of beige adipocytes in the white adipose tissue (WAT) of mice and humans, a process that has been extensively investigated. However, beige adipose tissue also develops during the peri-weaning period in mice, a developmental program that remains poorly understood. Here, we address this gap in our knowledge using genetic, imaging, physiologic, and genomic approaches. We find that, unlike cold-induced recruitment in adult animals, peri-weaning development of beige adipocytes occurs in a temperature- and sympathetic nerve-independent manner. Instead, the transcription factor B cell leukemia/lymphoma 6 (BCL6) acts in a cell-autonomous manner to regulate the commitment but not the maintenance phase of beige adipogenesis. Genome-wide RNA-sequencing (seq) studies reveal that BCL6 regulates a core set of genes involved in fatty acid oxidation and mitochondrial uncoupling, which are necessary for development of function...Continue Reading

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Citations

Mar 25, 2021·Nature Reviews. Molecular Cell Biology·Paul Cohen, Shingo Kajimura
Aug 1, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Leonardo A Rodriguez-LópezArmando R Tovar

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Methods Mentioned

BETA
fluorescence microscopy
RNA-seq

Software Mentioned

Clear
Imaris
Adipo

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