Distinct signal/response mechanisms regulate pax1 and QmyoD activation in sclerotomal and myotomal lineages of quail somites

Developmental Biology
A G BoryckiC P Emerson

Abstract

Pax1 and QmyoD are early sclerotome and myotome-specific genes that are activated in epithelial somites of quail embryos in response to axial notochord/neural tube signals. In situ hybridization experiments reveal that the developmental kinetics of activation of pax1 and QmyoD differ greatly, suggesting that myotome and sclerotome specification are controlled by distinct developmental mechanisms. pax1 activation always occurs in somite IV throughout development, indicating that pax1 regulation is tightly coordinated with early steps in somite maturation. In contrast, QmyoD is delayed and does not occur until embryos have 12-14 somites. At this time, QmyoD is the first of the myogenic regulatory factor (MRF) genes to be activated in preexisting somites in a rapid, anterior to posterior progression until the 22 somite stage, after which time QmyoD is activated in somite I immediately following somite formation. Experiments involving transplantation of newly formed somites to ectopic sites along the anterior to posterior embryonic axis were performed to distinguish the contributions of axial signals and somite response pathways to the developmental regulation of pax1 and QmyoD. These studies show that pax1 activation is regulated ...Continue Reading

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Citations

Aug 30, 2002·Current Opinion in Genetics & Development·Ava E Brent, Clifford J Tabin
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Mary Elizabeth PownallCharles P Emerson
Sep 29, 2009·Differentiation; Research in Biological Diversity·Josée SavageIlona S Skerjanc
Mar 7, 1998·Cell·S Tajbakhsh, R Spörle
Sep 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·W Zhao, G K Dhoot
Oct 27, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D M NodenC P Emerson
Aug 15, 2003·Development·Claudia LinkerChristophe Marcelle
Oct 20, 1999·Developmental Biology·C MarcelleM Bronner-Fraser
Jul 4, 1998·Mechanisms of Development·N KahaneC Kalcheim
Aug 1, 2009·Mechanisms of Development·Alaa Abou-ElhamdAndrea Münsterberg

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