Abstract
Isolated cultured murine brain macrophages (BM) were treated with supernatants of enriched astrocytic cultures. The astrocyte-conditioned medium (ACM) induced ramification of BM. In parallel, BM expressed voltage-gated outward K+ currents (I(K)) during the first 2 days after the application of ACM. However, in ramified BM which were treated once with ACM, I(K) disappeared 5 days after that treatment. In contrast, BM expressed I(K) over a period of more than 5 days when cells were treated daily with ACM. A blockade of I(K) by charybdotoxin or by kaliotoxin did not inhibit ramification of the cells. Furthermore, after application of low-concentrated ACM BM exhibited I(K) but did not change their morphology. It is suggested that in murine BM the ramification and the expression of I(K) are induced by distinct soluble factors derived from astrocytes.
References
Jan 1, 1992·Glia·A R Korotzer, C W Cotman
Dec 7, 1992·Neuroscience Letters·W NörenbergP Illes
Feb 1, 1992·The Journal of Membrane Biology·D J NelsonF Jow
Jan 1, 1992·Brain Research. Brain Research Reviews·W E Thomas
Jun 1, 1990·The Journal of Membrane Biology·L C McKinney, E K Gallin
Jan 1, 1985·Developmental Neuroscience·B H Juurlink, L Hertz
Aug 1, 1995·Pflügers Archiv : European journal of physiology·C EderU Heinemann
Jan 1, 1995·Neuroscience·H G FischerU Heinemann
Dec 1, 1994·Glia·J SieversH U Wottge
Dec 1, 1994·Glia·J SchmidtmayerJ Sievers
Jan 1, 1993·Glia·E A Ling, W C Wong
Sep 1, 1995·The Journal of Membrane Biology·C EderU Heinemann
Nov 15, 1996·Neuroscience Letters·C EderU Heinemann
Citations
Jan 8, 2000·Brain Research·T MöllerH Kettenmann
Nov 24, 1999·Brain Research. Developmental Brain Research·F AlliotB Pessac
Oct 7, 1998·Progress in Neurobiology·M A Cuadros, J Navascués
Jul 3, 1999·Neuroscience·R KleeC Eder
Nov 26, 2002·Journal of Physiology, Paris·N RochefortC Milleret
Sep 13, 2001·The European Journal of Neuroscience·T SchillingC Eder
Jun 17, 1998·The Journal of General Physiology·W ZhouT E DeCoursey
Jul 11, 2000·The European Journal of Neuroscience·C BoucseinC Nolte
Jul 16, 2005·The Journal of Physiology·Evan W Newell, Lyanne C Schlichter
Jan 15, 2014·Brain, Behavior, and Immunity·F Rohan WalkerMichael Nilsson
Oct 19, 2004·Molecular Immunology·Cornelia SpethSieghart Sopper
Aug 31, 2001·Microscopy Research and Technique·W Walz, L K Bekar
Dec 14, 1999·The European Journal of Neuroscience·C EderR Nitsch
Aug 4, 1998·The American Journal of Physiology·C Eder
Oct 3, 2002·Journal of Neurochemistry·D L TaylorJ M Pocock