PMID: 9175588May 2, 1997Paper

Distinct soluble astrocytic factors induce expression of outward K+ currents and ramification of brain macrophages

Neuroscience Letters
C EderU Heinemann

Abstract

Isolated cultured murine brain macrophages (BM) were treated with supernatants of enriched astrocytic cultures. The astrocyte-conditioned medium (ACM) induced ramification of BM. In parallel, BM expressed voltage-gated outward K+ currents (I(K)) during the first 2 days after the application of ACM. However, in ramified BM which were treated once with ACM, I(K) disappeared 5 days after that treatment. In contrast, BM expressed I(K) over a period of more than 5 days when cells were treated daily with ACM. A blockade of I(K) by charybdotoxin or by kaliotoxin did not inhibit ramification of the cells. Furthermore, after application of low-concentrated ACM BM exhibited I(K) but did not change their morphology. It is suggested that in murine BM the ramification and the expression of I(K) are induced by distinct soluble factors derived from astrocytes.

References

Jan 1, 1992·Glia·A R Korotzer, C W Cotman
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Jan 1, 1992·Brain Research. Brain Research Reviews·W E Thomas
Aug 1, 1995·Pflügers Archiv : European journal of physiology·C EderU Heinemann

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Citations

Jan 8, 2000·Brain Research·T MöllerH Kettenmann
Nov 24, 1999·Brain Research. Developmental Brain Research·F AlliotB Pessac
Oct 7, 1998·Progress in Neurobiology·M A Cuadros, J Navascués
Jun 17, 1998·The Journal of General Physiology·W ZhouT E DeCoursey
Jul 11, 2000·The European Journal of Neuroscience·C BoucseinC Nolte
Oct 19, 2004·Molecular Immunology·Cornelia SpethSieghart Sopper
Aug 31, 2001·Microscopy Research and Technique·W Walz, L K Bekar
Dec 14, 1999·The European Journal of Neuroscience·C EderR Nitsch
Aug 4, 1998·The American Journal of Physiology·C Eder

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