Distinct stages of adult hippocampal neurogenesis are regulated by running and the running environment

Hippocampus
Matthew R BednarczykKarl J L Fernandes

Abstract

Hippocampal neurogenesis continues into adulthood in mammalian vertebrates, and in experimental rodent models it is powerfully stimulated by exposure to a voluntary running wheel. In this study, we demonstrate that exposure to a running wheel environment, in the absence of running, is sufficient to regulate specific aspects of hippocampal neurogenesis. Adult mice were provided with standard housing, housing enriched with a running wheel or housing enriched with a locked wheel (i.e., an environment comparable to that of running animals, without the possibility of engaging in running). We found that mice in the running wheel and locked wheel groups exhibited equivalent increases in proliferation within the neurogenic niche of the dentate gyrus; this included comparable increases in the proliferation of radial glia-like stem cells and the number of proliferating neuroblasts. However, only running animals displayed increased numbers of postmitotic neuroblasts and mature neurons. These results demonstrate that the running wheel environment itself is sufficient for promoting proliferation of early lineage hippocampal precursors, while running per se enables newly generated neuroblasts to survive and mature into functional hippocampal...Continue Reading

References

Aug 12, 1977·Science·R A CumminsJ G Evans
Aug 1, 1997·Brain Research·F Gómez-PinillaV So
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Sep 7, 2000·The Journal of Comparative Neurology·T D PalmerF H Gage
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·B CzéhE Fuchs
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Jun 6, 2003·The European Journal of Neuroscience·Jason BrownH Georg Kuhn
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica E Malberg, Ronald S Duman
Dec 6, 2003·The European Journal of Neuroscience·Sebastian Jessberger, Gerd Kempermann
Dec 6, 2003·The European Journal of Neuroscience·Klaus FabelTheo D Palmer
Jul 20, 2004·Nature Genetics·Lei CaoMatthew J During
Jul 24, 2004·Trends in Neurosciences·Gerd KempermannGolo Kronenberg
Sep 24, 2004·The Journal of Comparative Neurology·Bettina SeriArturo Alvarez-Buylla
Jan 19, 2005·The European Journal of Neuroscience·Sebastien Couillard-DespresLudwig Aigner
Jan 28, 2005·The European Journal of Neuroscience·Elodie Bruel-JungermanClaire Rampon
Aug 23, 2006·Nature Reviews. Neuroscience·Jess Nithianantharajah, Anthony J Hannan
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tara L WalkerPerry F Bartlett
May 9, 2007·Nature Neuroscience·Nicolas ToniFred H Gage
Jun 15, 2007·Physiology & Behavior·Stefan BrenéMartin Werme
Dec 7, 2007·Nature Medicine·Joshua G HunsbergerRonald S Duman
Feb 12, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M KoehlD N Abrous
Feb 13, 2008·Brain Research·Catharine H DumanRonald S Duman
Feb 21, 2008·Neuromolecular Medicine·M Llorens-MartínJosé L Trejo
Jul 16, 2008·Nature Neuroscience·Nicolas ToniAlejandro F Schinder
Feb 3, 2009·Neuron·James B AimoneFred H Gage
Jul 17, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maura BoldriniVictoria Arango
Sep 15, 2009·Nature Neuroscience·Dori DerdikmanEdvard I Moser
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei DengFred H Gage
Mar 17, 2010·Hippocampus·Sarah DubreucqFrancis Chaouloff

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Citations

Feb 14, 2014·Cellular and Molecular Life Sciences : CMLS·Dirk-Jan Saaltink, Erno Vreugdenhil
Mar 19, 2016·Frontiers in Neuroendocrinology·Juan Triviño-ParedesBrian R Christie
Dec 30, 2014·Behavioural Brain Research·Sarah DubreucqFrancis Chaouloff
Dec 20, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Siu W TangBrian Leonard
Jun 8, 2017·PloS One·Nara Gyzely de Morais MagalhãesCristovam Wanderley Picanço Diniz
Aug 5, 2017·Cell and Tissue Research·Rebecca M Ruddy, Cindi M Morshead
Nov 5, 2019·Frontiers in Neuroanatomy·Camila Mendes de LimaCristovam Guerreiro Diniz

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