Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Tony KennaDerek G Doherty

Abstract

Gamma delta T cells are thought to mediate immune responses at epithelial surfaces. We have quantified and characterized hepatic and peripheral blood gamma delta T cells from 11 normal and 13 unresolved tumor-bearing human liver specimens. gamma delta T cells are enriched in normal liver (6.6% of T cells) relative to matched blood (0.9%; P = 0.008). The majority express CD4(-)CD8(-) phenotypes and many express CD56 and/or CD161. In vitro, hepatic gamma delta T cells can be induced to kill tumor cell lines and release interferon-gamma, tumor necrosis factor-alpha, interleukin-2 and interleukin-4. Analysis of V gamma and V delta chain usage indicated that V delta 3(+) cells are expanded in normal livers (21.2% of gamma delta T cells) compared to blood (0.5%; P = 0.001). Tumor-bearing livers had significant expansions and depletions of gamma delta T cell subsets but normal cytolytic activity. This study identifies novel populations of liver T cells that may play a role in immunity against tumors.

Citations

Aug 23, 2006·Cancer Immunology, Immunotherapy : CII·Tony KennaDerek G Doherty
Feb 25, 2014·Developmental and Comparative Immunology·Corinna SedlakWilhelm Gerner
Jul 30, 2009·Seminars in Immunopathology·Eszter NemethCliona O'Farrelly
Mar 22, 2016·Cellular & Molecular Immunology·Zongwen ShuaiM Eric Gershwin
Apr 12, 2016·Cellular & Molecular Immunology·Mark W RobinsonCliona O'Farrelly
Sep 11, 2014·Frontiers in Immunology·Neil RajoriyaPaul Klenerman
Sep 26, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Nobuyuki KawashimaHideaki Suda
Nov 29, 2016·Cellular & Molecular Immunology·Dang WuJian Huang
Aug 16, 2005·Biochimica Et Biophysica Acta·Niels SmakmanOnno Kranenburg
Nov 6, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·John A MengsholHugo R Rosen
Oct 23, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hans-Udo KasperUta Drebber
Nov 17, 2015·The Proceedings of the Nutrition Society·Melissa J ConroyJohn V Reynolds
Sep 25, 2019·Clinical & Translational Immunology·Lucy C SullivanGlen P Westall
Oct 20, 2019·Journal for Immunotherapy of Cancer·Bridget P KeenanRobin K Kelley
Jan 30, 2020·The Journal of Biological Chemistry·Katharine Jennifer GoodallDaniel Mark Andrews
Aug 10, 2017·Frontiers in Immunology·Heleen H Van AckerViggo F Van Tendeloo
Mar 31, 2019·International Journal of Molecular Sciences·Shin HwangNayoung Kim
Jun 12, 2020·World Journal of Gastroenterology : WJG·Qi-Hui ZhouZhi Chen
Jun 7, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bozgana A ManganDerek G Doherty
Nov 6, 2018·Frontiers in Immunology·Carolina Maiumi Shiromizu, Carolina Cristina Jancic
May 1, 2009·European Journal of Immunology·Olivier ToutiraisVéronique Catros
Oct 17, 2018·Nature Reviews. Gastroenterology & Hepatology·Jacintha O'SullivanJohn V Reynolds
Apr 3, 2020·Cells·Oliver Nussbaumer, Martin Thurnher
Dec 18, 2018·Frontiers in Immunology·Elizabeth C StahlBryan N Brown
Aug 9, 2020·Frontiers in Immunology·Yongyan Chen, Zhigang Tian
Jan 24, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hugo BarraguéEric Champagne
Jan 29, 2021·Journal of Immunology Research·Nilberto Dias de AraújoAllyson Guimarães Costa
Feb 16, 2021·Molecular Metabolism·Beatriz CicuéndezGuadalupe Sabio
Mar 6, 2021·Frontiers in Immunology·Yang LiXi Chen
Mar 19, 2021·Frontiers in Immunology·Cong QiJingxia Zhao
Apr 26, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Margaret R DunneThomas R Rogers
Feb 14, 2018·Immunology Letters·Andreea PetrascaDerek G Doherty
Jun 3, 2021·Vaccines·Elena Lo PrestiSerena Meraviglia
Jul 18, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ashanty M MeloMelissa J Conroy
Aug 3, 2021·Frontiers in Immunology·Eric de SousaMarkus Maeurer
Oct 29, 2021·Clinical Science·Michael L ChengSonya A MacParland

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