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Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus With Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

Christopher R MillerAndrew D Berti

Abstract

We present a case of endocarditis wherein organisms cultured from different valve leaflets yielded different daptomycin susceptibility from each other, and from organisms obtained from peripheral blood culture. Genomic analyses showed mutations in mprF, purR and agrA. Pharmacokinetic si...read more

Mentioned in this Paper

Laboratory Culture
Simulation
Daptomycin
Endocarditis
In Vivo
Blood culture
Staphylococcus aureus
Biological Evolution
beta-Lactams
Methicillin resistant Staphylococcus aureus (organism)
2
1
Paper Details
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Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus With Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

Christopher R MillerAndrew D Berti

PMID: 31932377

DOI: 10.1128/aac.01593-19

Abstract

We present a case of endocarditis wherein organisms cultured from different valve leaflets yielded different daptomycin susceptibility from each other, and from organisms obtained from peripheral blood culture. Genomic analyses showed mutations in mprF, purR and agrA. Pharmacokinetic si...read more

Mentioned in this Paper

Laboratory Culture
Simulation
Daptomycin
Endocarditis
In Vivo
Blood culture
Staphylococcus aureus
Biological Evolution
beta-Lactams
Methicillin resistant Staphylococcus aureus (organism)
2
1

Similar Papers Found In These Feeds

MRSA Infections

MRSA Infections or Methicillin-resistant Staphylococcus aureus infections are difficult to treat due to resistance to the beta-lactam family of antibiotics. MRSA infections are commonly acquired in hospitals. Discover the latest research on MRSA Infections here.

Related Papers

Nature Reviews. Drug Discovery

Daptomycin

Nature Reviews. Drug DiscoveryFebruary 6, 2004
Peter KirkpatrickJohn Lebbos
Paper Details
References
  • References25
  • Citations
123
  • References25
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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