Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children

Immunology
M RyanK H Mills

Abstract

Recent clinical trials have demonstrated that new generation acellular pertussis vaccines can confer protection against whooping cough. However, the mechanism of protective immunity against Bordetella pertussis infection induced by vaccination remains to be defined. We have examined cellular immune responses in children immunized with a range of acellular and whole cell pertussis vaccines. Immunization of children with a potent whole-cell vaccine induced B. pertussis-specific T cells that secreted interferon-gamma (IFN-gamma), but not interleukin-5 (IL-5). In contrast, T cells from children immunized with acellular pertussis vaccines secreted IFN-gamma and/or IL-5 following stimulation with B. pertussis antigens in vitro. These observations suggest that protective immunity conferred by whole-cell vaccines, like natural immunity, is mediated by type 1 T cells, whereas the mechanism of immune protection generated with acellular vaccines may be more heterogeneous, involving T cells that secreted type 1 and type 2 cytokines.

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Citations

Nov 18, 1998·Immunology Today·M T BradyK H Mills
Jul 11, 2001·Microbes and Infection·K H Mills
May 25, 2002·Allergy·Christoph Grüber, B Niggemann
Jun 22, 2012·Mucosal Immunology·R HiggsK H G Mills
Aug 17, 2002·The Pediatric Infectious Disease Journal·Frank DeStefanoUNKNOWN Vaccine Safety Datalink Research Group
Feb 4, 1999·Allergy·L NilssonN I Kjellman
Dec 15, 2010·Clinical and Vaccine Immunology : CVI·Ciaran M Skerry, Bernard P Mahon
Jul 16, 2002·Infection and Immunity·Jon B Bruss, George R Siber
May 29, 2008·Future Microbiology·Qiushui He, Jussi Mertsola
Jun 12, 2014·MBio·Clara Maria Ausiello, Antonio Cassone
Jan 21, 2014·The Journal of Infectious Diseases·William E SmallridgeEric T Harvill
Feb 16, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·C GrüberB Björkstén

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