Distinct Target-Specific Mechanisms Homeostatically Stabilize Transmission at Pre- and Post-synaptic Compartments

Frontiers in Cellular Neuroscience
Pragya GoelDion Dickman

Abstract

Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneously induces hypo-innervation on one target and hyper-innervation on the other. However, the expression mechanisms that achieve this exquisite target-specific homeostatic control remain enigmatic. Here, we identify the distinct target-specific homeostatic expression mechanisms. On the hypo-innervated target, an increase in postsynaptic glutamate receptor (GluR) abundance is sufficient to compensate for reduced innervation, without any apparent presynaptic adaptations. In contrast, a target-specific reduction in presynaptic neurotransmitter release probability is reflected by a decrease in active zone components restricted to terminals of hyper-innervated targets. Finally, loss of postsynaptic GluRs on one target induces a compartmentalized, homeostatic enhancement of presynaptic neurotransmitter release called presynaptic homeostatic potentiation (PHP) that can be precisely balanced with the adaptations required for both hypo- and hyper-innervation to maintain stable synaptic strength....Continue Reading

References

Aug 1, 1994·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·B A StewartC F Wu
Jul 3, 2002·Nature Reviews. Neuroscience·Harold L Atwood, Shanker Karunanithi
Jan 22, 2004·Nature Reviews. Neuroscience·Gina G Turrigiano, Sacha B Nelson
Nov 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard W DanielsAaron DiAntonio
Mar 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gang QinStephan J Sigrist
Aug 24, 2005·Nature Neuroscience·Giovanna GuerreroEhud Y Isacoff
Sep 2, 2005·Nature Neuroscience·Tobias M RasseStephan J Sigrist
Dec 2, 2006·International Review of Neurobiology·Aaron DiAntonio
Sep 18, 2007·Nature Neuroscience·Sarah Huntwork, J Troy Littleton
Jan 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Qingming HouHeng-Ye Man
May 13, 2008·Nature Neuroscience·Andreas SchmidStephan J Sigrist
Apr 21, 2009·Nature Reviews. Neuroscience·Tiago Branco, Kevin Staras
Dec 8, 2009·Science·Dion K Dickman, Graeme W Davis
Dec 17, 2009·Neuron·Ethan R GrafAaron DiAntonio
Apr 30, 2010·Nature·Hongbo JiaArthur Konnerth
Dec 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jean-Claude BéïqueRichard L Huganir
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Annika WeyhersmüllerJens Eilers
Nov 17, 2011·Cold Spring Harbor Perspectives in Biology·Gina Turrigiano
Dec 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eleonora PalmaRicardo Miledi
Dec 6, 2011·Nature Neuroscience·Nathalia VitureiraYukiko Goda
May 11, 2012·Nature Reviews. Neuroscience·Nancy A O'RourkeStephen J Smith
Jul 4, 2012·Cold Spring Harbor Perspectives in Biology·Wade G Regehr
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fredrick E HenryMichael A Sutton
Dec 21, 2012·Nature Reviews. Neuroscience·Hyungju Park, Mu-ming Poo
Jan 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jihye LeeJ Troy Littleton
May 7, 2013·Cell Reports·Dmitrij LjaschenkoRobert J Kittel
Oct 30, 2013·The Journal of Cell Biology·Nathalia Vitureira, Yukiko Goda
Nov 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jan E MelomJ Troy Littleton
Nov 12, 2014·Annual Review of Physiology·Graeme W Davis, Martin Müller
Apr 10, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Douglas W Allan, Stefan Thor

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Citations

Jan 16, 2021·Cellular and Molecular Life Sciences : CMLS·Pragya Goel, Dion Dickman

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Methods Mentioned

BETA
dissections
Localization Microscopy

Software Mentioned

MiniAnalysis
Nikon Elements
Excel
NIS Elements software
GraphPad Prism
MATLAB
NIS Elements General Analysis
pClamp
Clampfit

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