Distinct temporal patterns of macrophage-inflammatory protein-2 and KC chemokine gene expression in surgical injury

The Journal of Immunology : Official Journal of the American Association of Immunologists
Brian EndlichThomas A Hamilton

Abstract

In the present study the regulation of CXC chemokine expression was evaluated in full-thickness abdominal wounds in mice. During the first 24 h after injury, IL-1alphabeta, KC, macrophage-inflammatory protein (MIP)-2, and monocyte chemoattractant protein-1 were the predominant cytokines and chemokines produced; TNF-alpha was not detected. Chemokine mRNA expression and protein secretion occurred in two temporal stages. The first, which reached a maximum at 6 h, was associated with high levels of IL-1alpha and KC and low levels of MIP-2. This stage could be reproduced by intradermal injection of IL-1alpha or IL-1beta and was partially blocked by injection of neutralizing Ab against IL-1alpha but not IL-1beta. In animals depleted of circulating neutrophils, chemokine expression was reduced by nearly 70% during this stage. In the second stage, which peaked at 24 h after injury, modest but significant levels of IL-1beta were detected in association with low levels of KC and high levels of MIP-2. This pattern of chemokine expression could not be mimicked by injection of IL-1alpha or IL-1beta (even with prolonged exposure), although MIP-2 expression could be partially inhibited by intradermal injection of neutralizing Ab against IL-1b...Continue Reading

References

Sep 1, 1990·The Journal of Experimental Medicine·P Tekamp-OlsonA Cerami
Dec 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S D Wolpe, A Cerami
Nov 10, 1995·The Journal of Biological Chemistry·R M StrieterD Marriott
Jul 1, 1995·Clinical and Experimental Immunology·M Baggiolini
Jul 1, 1995·The Journal of Investigative Dermatology·E FeikenL R Lund
Jan 1, 1994·Annual Review of Immunology·C Gerard, N P Gerard
Jul 1, 1993·The Journal of Experimental Medicine·T KasamaS L Kunkel
Aug 1, 1993·The Journal of Dermatologic Surgery and Oncology·R A Clark
Nov 15, 1996·Biochimica Et Biophysica Acta·A Koj
Mar 1, 1997·Archives of Dermatological Research·H O RennekampffJ M Schröder
Feb 12, 1998·The New England Journal of Medicine·A D Luster
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A B LentschM J Edwards
Apr 29, 1998·Nature·M Baggiolini
Oct 27, 1999·Journal of Clinical Immunology·O M HowardJ M Wang
Nov 11, 1999·European Journal of Immunology·N A DilulioR L Fairchild
Aug 22, 2000·The Journal of Investigative Dermatology·R M DevalarajaA Richmond
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C L AddisonR M Strieter
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K HattarU Sibelius
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·V A FadokP M Henson

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Citations

Apr 26, 2003·Blood·Yalei DaiThomas A Hamilton
Nov 24, 2004·Clinical and Experimental Pharmacology & Physiology·Francisco J MiñanoRosario Maldonado
Apr 25, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Deepak V KilpadiWilliam A Wooden
Jan 26, 2007·Alcoholism, Clinical and Experimental Research·Daniel J FitzgeraldElizabeth J Kovacs
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel M McLoughlinArthur O Tzianabos
Aug 2, 2017·Clinical and Experimental Pharmacology & Physiology·Hiroyasu SakaiYoshihiko Chiba
Nov 11, 2017·European Journal of Medical Research·Juliet DavidChihaya Koriyama
Jan 31, 2019·Mucosal Immunology·Fang BianCintia S de Paiva
Jul 10, 2004·Clinical and Diagnostic Laboratory Immunology·Patricia A ManderscheidPaul R Knight
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takuya IyodaYoshiro Kobayashi
Sep 10, 2005·The Journal of Biological Chemistry·Leonardo H TravassosMaria Cristina Plotkowski
Jun 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rachel M McLoughlinJean C Lee
Mar 17, 2005·Fetal and Pediatric Pathology·Akhil MaheshwariAtilano Lacson
Sep 22, 2007·Journal of Leukocyte Biology·Jean M DaleyJorge E Albina
Feb 7, 2018·Frontiers in Cellular and Infection Microbiology·Janet Z LiuVictor Nizet
Sep 13, 2007·Experimental Lung Research·Yoko ItoMasaharu Nishimura
Mar 23, 2013·Journal of Leukocyte Biology·Tomasz HerjanThomas A Hamilton
Nov 8, 2012·European Journal of Pain : EJP·E U CarreiraT M Cunha
Nov 14, 2020·Anesthesia and Analgesia·Andreas MargrafJan Rossaint
Jul 1, 2008·Toxicon : Official Journal of the International Society on Toxinology·Alessandra Pareja-SantosCarla Lima
Feb 22, 2012·Microbial Pathogenesis·Josefa B da SilvaElizabeth A L Martins

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