Distinct timing of neurogenesis of ipsilateral and contralateral retinal ganglion cells

The Journal of Comparative Neurology
Florencia MarcucciCarol A Mason

Abstract

In higher vertebrates, the circuit formed by retinal ganglion cells (RGCs) projecting ipsilaterally (iRGCs) or contralaterally (cRGCs) to the brain permits binocular vision and depth perception. iRGCs and cRGCs differ in their position within the retina and in expression of transcription, guidance and activity-related factors. To parse whether these two populations also differ in the timing of their genesis, a feature of distinct neural subtypes and associated projections, we used newer birthdating methods and cell subtype specific markers to determine birthdate and cell cycle exit more precisely than previously. In the ventrotemporal (VT) retina, i- and cRGCs intermingle and neurogenesis in this zone lags behind RGC production in the rest of the retina where only cRGCs are positioned. In addition, within the VT retina, i- and cRGC populations are born at distinct times: neurogenesis of iRGCs surges at E13, and cRGCs arise as early as E14, not later in embryogenesis as reported. Moreover, in the ventral ciliary margin zone (CMZ), which contains progenitors that give rise to some iRGCs in ventral neural retina (Marcucci et al., 2016), cell cycle exit is slower than in other retinal regions in which progenitors give rise only to ...Continue Reading

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Citations

Apr 20, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Onkar B SawantSujata Rao
Aug 26, 2020·Ophthalmic Genetics·Julia ErnstKen K Nischal
Jul 7, 2019·International Journal of Molecular Sciences·Verónica Murcia-Belmonte, Lynda Erskine
May 13, 2020·Annual Review of Vision Science·Carol Mason, Nefeli Slavi
Mar 31, 2021·Cellular and Molecular Life Sciences : CMLS·Jianyi Lyu, Xiuqian Mu

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