Distinct Tissue Mineral Density in Plate- and Rod-like Trabeculae of Human Trabecular Bone

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Ji WangX Edward Guo

Abstract

Trabecular bone quality includes both microstructural and intrinsic tissue mineralization properties. However, the tissue mineralization in individual trabeculae of different trabecular types and orientations has not yet been investigated. The aim of this study was to develop an individual trabecula mineralization (ITM) analysis technique to determine tissue mineral density (TMD) distributions in plate- and rod-like trabeculae, respectively, and to compare the TMD of trabeculae along various orientations in micro-computed tomography (μCT) images of trabecular bone samples from the femoral neck, greater trochanter, and proximal tibia. ITM analyses indicated that trabecular plates, on average, had significantly higher TMD than trabecular rods. In addition, the distribution of TMD in trabecular plates depended on trabecular orientation with the lowest TMD in longitudinal plates and the highest TMD in transverse plates. Conversely, there was a relatively uniform distribution of TMD among trabecular rods, with respect to trabecular orientation. Further analyses of TMD distribution revealed that trabecular plates had higher mean and peak TMD, whereas trabecular rods had a wider TMD distribution and a larger portion of low mineralized...Continue Reading

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Citations

Jan 25, 2018·Proceedings of the National Academy of Sciences of the United States of America·Alessandro Marturano-KruikGordana Vunjak-Novakovic
Sep 13, 2018·BMC Musculoskeletal Disorders·Klemens TriebBeatrix Grubeck-Loebenstein
Apr 3, 2019·Evolutionary Bioinformatics Online·Ayesha SohailMuhammad Abid
May 15, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y Eric YuX Edward Guo
Sep 23, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Yoshihiro ObataClaire Acevedo

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