Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects

Endocrinology and Metabolism
Jong Han ChoiMin-Seon Kim

Abstract

Blood levels of many hormones show rhythmic fluctuations with variable duration of cycles. Clusterin/apolipoprotein J is a glycoprotein which is highly expressed in the plasma and has modulatory roles in immune and inflammatory reactions, neurobiology, lipid metabolism, and leptin signaling. In this study, we examined the diurnal fluctuations of plasma clusterin concentrations in lean and obese young men. For the study, 14 subjects (five lean and five obese men; two lean and two obese women) were admitted to the research ward and blood samples were drawn every 30 minutes during light-on period (6:00 AM to 10:00 PM) and every hour during light-off period. Notably, plasma clusterin concentrations displayed a unique ultradian rhythm with five cycles a day in both men and women. During the light-on period, circulating clusterin levels showed fluctuating curves with 4 hours regular intervals with sharp peaks and troughs. In contrast, single oscillation curve during light-off exhibited a smoothened/lower peak and longer (8-hour) duration. In obese men, these cycles were phase-advanced by approximately 1 hour, and had reduced amplitude of fluctuating curves and blunted diurnal pattern. Cyclic fluctuations of plasma clusterin were pres...Continue Reading

References

Oct 1, 1992·Journal of Biochemistry·N H Choi-MiuraM Tomita
Jan 1, 1991·Cytogenetics and Cell Genetics·T TobeN Shimizu
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Aug 23, 2005·Nature Cell Biology·Honglai ZhangCun-Yu Wang
Feb 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Eunheui JeongMin-Seon Kim

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Citations

Apr 25, 2019·Journal of Clinical Medicine·Drew WatsonMinnie M Sarwal
Aug 4, 2021·Progress in Neurobiology·Telma QuintelaCecília R A Santos

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BETA
ELISA

Software Mentioned

SPSS

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