PMID: 6965035Jan 1, 1982Paper

Distinction between normal and leukemic bone marrow by water protons nuclear magnetic resonance relaxation times

Magnetic Resonance Imaging
S ShahS H Advani

Abstract

Pulsed nuclear magnetic resonance studies have been carried out on bone marrow of normal human subjects and patients with leukemia: chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). It was observed that the proton spin-lattice relaxation time (T1) value was discriminatory in the normal and leukemic cases with a statistical significance of (p less than 0.01). Ouabain treatment of cells did not show any perceptible change of T1 value when compared with the nontreated cells, indicating that the concomitant cation effluxes do not affect spin-lattice relaxation time. The water contents of normal, leukemic, and ouabain treated cells were in the range 60%-80%. Higher Fe levels were encountered in the normal than the leukemic samples, while levels of Zn, Cu, Mn, Co, and Ni were elevated in the leukemic samples compared with the normals. Despite the T1 differences observed, the multiparameter studies do not uniquely pinpoint factors responsible for the elevation of T1 in the malignant state.

References

Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·C F HazelwoodB L Nichols
Dec 22, 1972·Science·I D WeismanD Burk
Mar 19, 1971·Science·R Damadian
Feb 12, 1965·Science·C B BRATTONJ W WEINBERG

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Citations

Apr 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W NegendankC Kellogg
Jan 1, 1992·Pediatric Radiology·T M Simonson, S C Kao
Jan 1, 1988·Leukemia Research·R M HenkelmanM Baker

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