Distinction between rhinovirus-induced acute asthma and asthma-augmented influenza infection

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
G V GuibasN G Papadopoulos

Abstract

Rhinovirus (RV) is an established trigger of asthma attacks, whereas such a link is less consistent for influenza virus (IFV). In the context of precision medicine, we hypothesized that IFV infection may cause a condition essentially different from RV, and we investigated this by evaluating clinical characteristics of RV/IFV-positive and -negative children with respiratory symptoms and/or fever. One thousand two hundred and seven children, 6 months to 13 years old, hospitalized for flu-like illness were recruited in this cross-sectional study. Collected information included demographics, medical history, symptoms/physical findings/diagnosis at presentation and treatment. Nasal secretions were PCR-tested for IFV/RV. Associations were evaluated with adjusted logistic regression models. Rhinovirus positivity was associated with an asthma-like presentation, including increased wheeze/effort of breathing/diagnosis of acute asthma, and decreased fever/vomiting. Conversely, IFV+ children presented with less wheeze/effort of breathing/diagnosis of acute asthma, while they were more frequently febrile. In those with previous asthma history, both viruses induced wheeze; however, IFV was uniquely associated with a more generalised and sev...Continue Reading

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Citations

Jul 26, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Maciej ChalubinskiMarek L Kowalski
Nov 20, 2019·Allergy, Asthma & Immunology Research·Styliani TakaNikolaos G Papadopoulos
Dec 14, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham RobertsJudith A Woodfolk
Jul 6, 2020·Allergy·Tuomas JarttiNikolaos G Papadopoulos

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