Distinction of basaloid squamous cell carcinoma from adenoid cystic and small cell undifferentiated carcinoma by immunohistochemistry

Human Pathology
W G Morice, J A Ferreiro

Abstract

Basaloid squamous cell carcinoma (BSCC) is a recently recognized variant of squamous cell carcinoma (SCC) with a predilection to occur in the tongue base, hypopharynx, and supraglottic larynx. In smal biopsy specimens, these tumors can be difficult to distinguish from small cell undifferentiated carcinoma (SCUC) and adenoid cystic carcinoma (ACC). Monoclonal antibodies reactive with cytokeratin (AE1/AE3, 34betaE12, Cam 5.2) as well as a variety of other cellular antigens (vimentin, actin, desmin, chromogranin, synaptophysin, CD57, neuron-specific enolase [NSE], and S100) were used in an immunoperoxidase method with paraffin-embedded tissue to phenotypically characterize 23 cases of BSCC, 10 cases of SCUC, and 15 cases of ACC. The neoplastic cells in 22 of the 23 cases of BSCC reacted with the high-molecular-weight cytokeratin antibody 34betaE12, whereas no reactivity was seen in any of the 10 cases of SCUC. This pattern of 34betaE12 reactivity more consistently differentiated BSCC from SCUC than did reactivity with the neuroendocrine markers chromogranin, synaptophysin, CD57, and NSE. These findings show that immunoperoxidase stains performed on paraffin-embedded tissue are potentially useful in establishing a diagnosis of basa...Continue Reading

Citations

Oct 7, 2000·The American Journal of Surgical Pathology·M PapottiJ Albores-Saavedra
Apr 1, 2011·The Journal of Laryngology and Otology·O ChoussyD Dehesdin
Dec 18, 2010·Head and Neck Pathology·James S Lewis
Nov 20, 2019·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Mehdi Nikkhah
Mar 21, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bruce M Wenig
May 29, 2002·Pathology International·Tomoyuki HishidaGen Iinuma
Dec 4, 2003·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T NoguchiS Yokoyama
Jul 8, 2009·Diagnostic Cytopathology·Deborah J Chute, Edward B Stelow
Dec 25, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Tae Hwan HaTae Hoon Oh
Jul 15, 2015·The Laryngoscope·Pariket M DubalJean Anderson Eloy
Sep 13, 2000·The Laryngoscope·A F PaulinoA G Huvos
Jul 20, 2002·Acta Oto-laryngologica·Ozden TulunayTevfik Aktürk
Aug 9, 2001·International Journal of Surgical Pathology·Laura VibertiGianni Bussolati
Oct 14, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y KobayashiT Shimoda
Jun 1, 2014·Archives of Pathology & Laboratory Medicine·Akeesha A ShahEdward B Stelow
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bruce M Wenig
Jun 1, 2016·Virchows Archiv : an International Journal of Pathology·Tokiko NakaiChiho Ohbayashi
Feb 23, 2017·Advances in Therapy·Fernando LópezAlfio Ferlito
Oct 29, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sonam PuriJessica M Clement
Aug 9, 2001·International Journal of Surgical Pathology·Lisa A. Cerilli, Mark R. Wick
Sep 15, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·M PapottiG Bussolati
May 29, 2004·Current Opinion in Otolaryngology & Head and Neck Surgery·Peter ZbärenEdouard Stauffer
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Bai-Hua ZhangJie He
Jul 1, 2010·Head and Neck Pathology·James S LewisSamir K El-Mofty
Jan 25, 2013·Applied Immunohistochemistry & Molecular Morphology : AIMM·Deepa R ManeSeema Hallikerimath
Feb 10, 2006·Journal of Cutaneous Pathology·Tomoko MitsuhashiMichio Shimizu
Feb 3, 2016·Head and Neck Pathology·Alessandro Franchi
Dec 14, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer M BolandDavid J Schembri-Wismayer
Jul 24, 2004·Archives of Pathology & Laboratory Medicine·Zhanyong BingMahmoud A Eltorky
Mar 8, 2000·Archives of Pathology & Laboratory Medicine·F Vakar-López, J Abrams
Oct 18, 2000·Archives of Pathology & Laboratory Medicine·M ZámecníkR Curík

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