Distinctive bone regeneration of calvarial defects using biphasic calcium phosphate supplemented ultraviolet-crosslinked collagen membrane

Journal of Periodontal & Implant Science
Inpyo HongSeong-Ho Choi

Abstract

To overcome several drawbacks of chemically-crosslinked collagen membranes, modification processes such as ultraviolet (UV) crosslinking and the addition of biphasic calcium phosphate (BCP) to collagen membranes have been introduced. This study evaluated the efficacy and biocompatibility of BCP-supplemented UV-crosslinked collagen membrane for guided bone regeneration (GBR) in a rabbit calvarial model. Four circular bone defects (diameter, 8 mm) were created in the calvarium of 10 rabbits. Each defect was randomly allocated to one of the following groups: 1) the sham control group (spontaneous healing); 2) the M group (defect coverage with a BCP-supplemented UV-crosslinked collagen membrane and no graft material); 3) the BG (defects filled with BCP particles without membrane coverage); and 4) the BG+M group (defects filled with BCP particles and covered with a BCP-supplemented UV-crosslinked collagen membrane in a conventional GBR procedure). At 2 and 8 weeks, rabbits were sacrificed, and experimental defects were investigated histologically and by micro-computed tomography (micro-CT). In both micro-CT and histometric analyses, the BG and BG+M groups at both 2 and 8 weeks showed significantly higher new bone formation than the ...Continue Reading

References

Jun 1, 1987·Journal of Biomedical Materials Research·M E NimniK Sheikh
May 1, 1988·Plastic and Reconstructive Surgery·C DahlinS Nyman
Apr 6, 2001·Journal of Periodontology·P Bunyaratavej, H L Wang
Sep 3, 2003·Periodontology 2000·Christoph H F Hämmerle, Ronald E Jung
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·R Z LeGerosJ P LeGeros
May 10, 2005·Clinical Oral Implants Research·Daniel RothamelJürgen Becker
Mar 27, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ju-Ha SongHae-Won Kim
Jul 30, 2010·Clinical Oral Implants Research·Maria Retzepi, N Donos
May 18, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Marco C BottinoGregg M Janowski
Nov 7, 2013·Clinical Oral Implants Research·J HaoN P Lang
Dec 18, 2015·Journal of Materials Science. Materials in Medicine·Natalia DavidenkoRuth E Cameron
Oct 10, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hyung-Chul PaeSeong-Ho Choi

❮ Previous
Next ❯

Citations

Jan 9, 2021·Journal of Dentistry·Manuel Toledano-OsorioRaquel Osorio
Feb 27, 2021·Journal of Periodontal & Implant Science·Inpyo HongSeong Ho Choi

❮ Previous
Next ❯

Software Mentioned

NRecon
SPSS
Case Viewer

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.