Distinctive clinicopathological features of adenocarcinoma in situ and minimally invasive adenocarcinoma of the lung: A retrospective study

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Hironori IshidaKunihiko Kobayashi

Abstract

The aim of this study was to investigate distinguishing clinicopathological features, in addition to histological invasiveness, in adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) of the lung. Patients with lung adenocarcinoma who underwent surgery at our hospital between 2007 and 2014 were reviewed, focusing on computed tomography (CT) images, operative procedures and clinical outcomes, histopathology, Ki-67 immunostaining, and EGFR-mutation status. EGFR mutations were examined using a peptide nucleic acid-locked nucleic acid PCR clamp method. Group comparisons were investigated by Mann-Whitney U or Fisher's exact tests. Of 629 patients with lung adenocarcinoma who underwent surgery, 91 (14%) of 103 AIS (n = 34) or MIA (n = 69) tumors were reviewed. The ratio of male to female patients with MIA compared to AIS was significantly higher (p <  0.02). Of 103 tumors, 99 (96%) were non-mucinous. By CT, 74% of AIS appeared as pure ground-glass nodules and 75% of MIAs as part-solid ground-glass nodules. Pathological tumor diameters and Ki-67 labeling index (LI) values were significantly greater for MIAs compared to AIS (p <  0.001 for both). A Ki-67 LI of ≥2.8% indicated the presence of an MIA rather than an AI...Continue Reading

Citations

Dec 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xia ZouYan Zhang
Feb 6, 2021·The Journal of Thoracic and Cardiovascular Surgery·Zhen-Bin QiuWen-Zhao Zhong
Feb 25, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Zhihua LiLiang Chen
Mar 29, 2021·The Journal of Thoracic and Cardiovascular Surgery·Brian Mitzman

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