PMID: 15249856Jul 14, 2004Paper

Distinctive dermal clear cell mesenchymal neoplasm: clinicopathologic analysis of five cases

The American Journal of Dermatopathology
Alexander J F Lazar, Christopher D M Fletcher

Abstract

Dermal clear cell tumors are not common. This group of lesions is comprised primarily of clear cell adnexal lesions, balloon cell melanocytic lesions, and metastatic clear cell carcinomas. We report the clinicopathologic features of five cases of a novel dermal clear cell neoplasm that appears mesenchymal in nature. The affected patients included 3 men and 2 women ranging in age from 38 to 70 (median, 45 years). All the lesions occurred on the lower limb. Clinically described as smooth cutaneous nodules, size ranged from 0.5 to 2.5 cm in greatest dimension and the lesions were present from weeks to 5 years prior to excision. Situated in the reticular dermis, the tumors usually extended to involve the subcutis with sparing of the papillary dermis. The tumors were composed of large optically clear cells with vesicular nuclei. The lesions entrapped adnexal structures and thin dermal collagen fibers. Mitoses were rare (less than 1 per 25 hpf). A single case showed more pleomorphic nuclei as well as quite frequent mitoses and was considered of uncertain biologic potential. Immunohistochemistry revealed reactivity only for NKI-C3 (5/5 cases), CD68 (2/5 cases), and vimentin (2/3 cases); melanocytic, epithelial, and lymphoid markers we...Continue Reading

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Citations

Aug 27, 2005·The American Journal of Dermatopathology·Alice N LeeLisa M Cohen
Apr 7, 2007·The American Journal of Dermatopathology·Tien Anh TranJ Andrew Carlson
Apr 20, 2012·The American Journal of Dermatopathology·Asok Biswas, Meera Mahalingam
Feb 19, 2008·The American Journal of Surgical Pathology·Bernadette LieglChristopher D M Fletcher
Sep 1, 2011·Surgical Pathology Clinics·Aaron Auerbach, David S Cassarino
Mar 13, 2008·Journal of Cutaneous Pathology·Alde Carlo P GavinoNasir A Bakshi
May 26, 2016·Journal of Cutaneous Pathology·Mar Llamas-VelascoLuis Requena
Nov 10, 2016·The American Journal of Dermatopathology·Ana Isabel TeixeiraHeinz Kutzner
Jan 8, 2014·The American Journal of Dermatopathology·Viktoryia KazlouskayaJoan Mones
May 31, 2017·Journal of Cutaneous Pathology·Lauren N StuartJerad M Gardner
Mar 29, 2016·World Journal of Methodology·Mar Llamas-VelascoThomas Mentzel
Jul 23, 2014·The American Journal of Dermatopathology·Marián SvajdlerDmitry V Kazakov
Apr 23, 2020·Diagnostics·Joon Hyuk Choi, Jae Y Ro
Jan 21, 2021·Journal of Cutaneous Pathology·Michela M ParadisoJennifer A Sopkovich
Nov 6, 2007·Archives of Pathology & Laboratory Medicine·Iskander H Chaudhry, Artur Zembowicz
Aug 20, 2021·The American Journal of Dermatopathology·Pedro ZaballosLuis Requena

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