journal cover

Distinctive expression of T cell guiding molecules in human autoimmune lymph node stromal cells upon TLR3 triggering

Scientific Reports

Jan 31, 2018

Janine HähnleinL G M van Baarsen

Abstract

Infections are implicated in autoimmunity. Autoantibodies are produced in lymphoid tissue where lymph node stromal cells (LNSCs) regulate lymphocyte function. Infections can alter the interaction between LNSCs and lymphocytes resulting in defective immune responses. In rheumatoid arthri...read more

Mentioned in this Paper

MX1 gene
Lymphocyte Count Measurement
Lymphocyte Function
Interleukin-6
Recombinant Chemokine
Recombinant Interleukin-6
Recombinant Interleukin-8
Toll-Like Receptor 3
Specimen Type - Lymphocytes
Lymph Nodes
4
11
Paper Details
References
  • References70
  • Citations1
12345...

Similar Papers Found In These Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Inflammatory Biomarkers

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Chemokines & Chemokine Receptors

Chemokines are a subset of cytokines which induce chemotaxis in cells expressing chemokine receptors. Chemokines can be broadly categorized into two functional subgroups, homeostatic (basal expression in lymphoid tissues for surveillance purposes) or inflammatory (released during injury to recruit immune effector cells). Chemokine receptors are G-protein coupled receptors which, upon chemokine binding, induce calcium influx into the cell. Find the latest research on chemokines and chemokine receptors here.

Systemic Autoimmunity

Systemic autoimmunity is a complex disease process that results from a loss of immunological tolerance, characterized by the inability of the immune system to discriminate self from non-self. Discover the latest research on Systemic Autoimmunity here.

Extracellular Matrix Adhesion

Multiprotein adhesion structures allow the interaction of a cell with the extracellular matrix comprised of extracellular molecules that ensure tissue integrity and play a role in cell growth, migration, and differentiation. Here is the latest research.

Interferon Stimulated Genes

Interferon-stimulated gene products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. Discover the latest research on interferon-stimulated genes here.

© 2020 Meta ULC. All rights reserved

Distinctive expression of T cell guiding molecules in human autoimmune lymph node stromal cells upon TLR3 triggering

Scientific Reports

Jan 31, 2018

Janine HähnleinL G M van Baarsen

PMID: 29379035

DOI: 10.1038/s41598-018-19951-5

Abstract

Infections are implicated in autoimmunity. Autoantibodies are produced in lymphoid tissue where lymph node stromal cells (LNSCs) regulate lymphocyte function. Infections can alter the interaction between LNSCs and lymphocytes resulting in defective immune responses. In rheumatoid arthri...read more

Mentioned in this Paper

MX1 gene
Lymphocyte Count Measurement
Lymphocyte Function
Interleukin-6
Recombinant Chemokine
Recombinant Interleukin-6
Recombinant Interleukin-8
Toll-Like Receptor 3
Specimen Type - Lymphocytes
Lymph Nodes
4
11

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References70
  • Citations1
12345...
/papers/distinctive-expression-of-t-cell-guiding/29379035