Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases

Veterinary Ophthalmology
Enry Garcia da SilvaArmien Anibal

Abstract

Canine optic nerve hypoplasia (ONH) and aplasia (ONA) are significant neuro-ophthalmologic disorders that have been reported in several species. The purpose of this study was to describe the distinctive histopathologic features of ONH and ONA in canine patients identified from a collection of 20 000 ocular submissions at the comparative ocular pathology laboratory of Wisconsin from 1989 to 2006. The following information about ONH and ONA cases was collected: signalment, and clinical and gross findings, including unilateral vs. bilateral involvement. Microscopic evaluation was performed, with attention to optic nerve malformation, retinal ganglion cell (RGC) and nerve fiber layer (NFL) loss, and retinal disorganization. The distribution of retinal vasculature was recorded and a search for unusual findings of ONH and ONA was performed. Information and histologic documentation was available for 13 cases. Eight cases of ONH and five cases of ONA were identified. The average group age was 20.2 months and 16.1 months, respectively. The most common breed was the Shih Tzu (3/13). ONH usually presented bilaterally (7/8); all ONA cases presented as a unilateral disease (5/5). The morphologic findings in the optic nerve (ON) in ONH inclu...Continue Reading

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Citations

Aug 21, 2008·Current Neurology and Neuroscience Reports·Mark Borchert, Pamela Garcia-Filion
Mar 6, 2009·Veterinary Ophthalmology·Wes A BaumgartnerDaniel B Paulsen
Aug 25, 2015·Veterinary Ophthalmology·Elizabeth DombrowskiBruce H Grahn
Oct 16, 2020·Veterinary Ophthalmology·Inês Q Saraiva, Esmeralda Delgado

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