PMID: 9553809Apr 29, 1998Paper

Distinctive p53 and mdm2 immunohistochemical expression profiles suggest different pathogenetic pathways in poorly differentiated endometrial carcinoma

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Robert A SoslowChristina Isacson

Abstract

Endometrial serous carcinoma (ESC) and FIGO (International Federation of Gynecology and Obstetrics) grade 3 endometrioid adenocarcinoma (EC) are high-grade endometrial tumors that have different clinical and morphologic attributes. Alteration of p53 tumor suppressor protein function has been implicated in the pathogenesis of both tumors, although the mechanisms may differ. We sought to investigate this difference by comparing immunohistochemical expression of p53 and mdm2. p53 immunoreactivity often correlates with gene mutation, whereas increased mdm2 expression is linked to complex formation with wild-type p53 resulting in its inactivation. Twenty cases of ESC and 21 cases of EC were evaluated and an immunoreactivity score (IRS) was assigned using both the percentage of cells stained and the intensity of staining. The overall IRSs were significantly different in ESCs versus ECs for both p53 and mdm2 (p < 0.001 and p < 0.01, respectively). Strong mean immunoreactivity for p53 was detected in 15 (75%) ESCs as compared to only weak mean immunoreactivity in 17 (81%) ECs. Conversely, for mdm2 expression, 17 (81%) ECs had moderate mean immunoreactivity whereas 9 (45%) ESCs showed only weak mean immunoreactivity. mdm2 expression mor...Continue Reading

Citations

Aug 15, 2000·Breast Cancer Research and Treatment·R A SoslowM P Osborne
Oct 27, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Karuna GargRobert A Soslow
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M. HoriM. Hori
Dec 8, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R A SoslowR N Baergen
Feb 24, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·H Yaziji, A M Gown
Apr 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kathryn TerryImmaculata De Vivo
Jun 22, 2014·Seminars in Diagnostic Pathology·Sarah Chiang, Robert A Soslow
May 6, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan ZhaoMinghong Zhao
Mar 1, 2011·Surgical Pathology Clinics·Esther Oliva, Robert A Soslow
Feb 12, 2011·Seminars in Diagnostic Pathology·Diana Lim, Esther Oliva
Dec 18, 2012·Histopathology·Robert A Soslow
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