Distinctive pathological mechanisms involved in primary progressive aphasias

Neurobiology of Aging
Cristian E LeytonJillian J Kril

Abstract

Primary progressive aphasia (PPA) comprises a heterogeneous group of neurodegenerative conditions that can be classified in three cliniconeuroanatomic syndromes. Limited information exists, however, about patterns of neuropathologic spreading and microscopic changes underpinning each syndrome. We performed an analysis of a longitudinal in vivo cohort and a postmortem PPA cohort to investigate neurodegeneration over time and to quantify microscopic changes in key language brain areas. The longitudinal analyses demonstrated distinctive patterns of topological extension of brain atrophy. Although semantic variant (sv-PPA) showed an eccentric pattern, nonfluent and/or agrammatic (nfv-PPA) and logopenic (lv-PPA) variants showed additional multifocal extension. The quantitative pathology showed that sv-PPA had neuronal loss and thinning in BA 38, whereas nfv-PPA showed thinning in BA 44/45 and evidence of microscopic involvement in BA 40/22. Although lv-PPA showed neuronal loss focused on BA 40/22, imaging results demonstrated widespread left-sided brain atrophy. These analyses provide an account of the pathologic process whereby each variant has stereotypical patterns of brain atrophy extension, which is largely determined by the sp...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jun 1, 1982·Annals of Neurology·M M Mesulam
Aug 1, 1997·Neuroscience·J J KrilH Cartwright
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Jan 2, 2003·Annals of Neurology·Sreepadma P SontyDarren R Gitelman
Aug 7, 2003·Brain : a Journal of Neurology·Peter J NestorJohn R Hodges
Aug 21, 2003·Neurobiology of Aging·G M HallidayJ J Kril
Oct 1, 1955·Journal of Consulting Psychology·R M REITAN
Mar 3, 2004·Annals of Neurology·Maria Luisa Gorno-TempiniBruce L Miller
Oct 30, 2004·Journal of Clinical and Experimental Neuropsychology·Nancy J WildeDavid S Tulsky
Apr 15, 2006·Brain : a Journal of Neurology·Keith A JosephsRonald C Petersen
Sep 16, 2006·International Journal of Geriatric Psychiatry·Eneida MioshiJohn R Hodges
Oct 20, 2006·Nature·Jorge J PalopLennart Mucke
Aug 10, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rita R Romito-DiGiacomoKarl Herrup
Apr 17, 2008·Annals of Neurology·Marsel MesulamEileen H Bigio
Jul 18, 2008·Neurology·M L Gorno-TempiniB L Miller
Apr 21, 2009·Neuron·William W SeeleyMichael D Greicius
Jun 10, 2009·Brain : a Journal of Neurology·Marsel MesulamSandra Weintraub
Aug 15, 2009·NeuroImage·Jonathan D RohrerJason D Warren
Oct 7, 2009·Brain : a Journal of Neurology·John R HodgesKaralyn Patterson
Jan 16, 2010·Brain and Language·Sharon AshMurray Grossman
Jun 15, 2010·Brain : a Journal of Neurology·Stephen M WilsonMaria Luisa Gorno-Tempini
Aug 18, 2010·Neurology·D GunawardenaM Grossman
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephen M WilsonMaria Luisa Gorno-Tempini
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
Jun 7, 2011·Acta Neuropathologica·Ian R A MackenzieVirginia M Y Lee
Jun 8, 2011·Brain : a Journal of Neurology·Julio Acosta-CabroneroPeter J Nestor
Jun 15, 2011·Brain : a Journal of Neurology·Sebastiano GalantucciMaria Luisa Gorno-Tempini
Aug 23, 2011·Brain : a Journal of Neurology·Sharpley HsiehJohn R Hodges
Mar 3, 2012·Brain : a Journal of Neurology·Keith A JosephsJennifer L Whitwell
Apr 24, 2012·Brain : a Journal of Neurology·Tamar GefenM-Marsel Mesulam

❮ Previous
Next ❯

Citations

Jan 31, 2017·Annals of Neurology·Edoardo G SpinelliMaria Luisa Gorno-Tempini
Oct 4, 2017·Brain : a Journal of Neurology·Kamalini G RanasingheSrikantan S Nagarajan
Jan 31, 2018·Neuropsychological Rehabilitation·Aaron M MeyerRhonda B Friedman
Nov 7, 2017·Human Brain Mapping·Jeffrey S PhillipsMurray Grossman
Oct 19, 2017·Journal of the International Neuropsychological Society : JINS·Christa L WatsonMaria Luisa Gorno-Tempini
Jul 16, 2019·Journal of Clinical and Experimental Neuropsychology·Catherine MerckSolène Kalénine
Jun 5, 2020·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Mario F MendezOleg Yerstein
Nov 7, 2017·Frontiers in Neuroscience·Andreia V FariaSusumu Mori
Jul 20, 2018·Alzheimer's Research & Therapy·Jolien SchaeverbekeRik Vandenberghe
Aug 16, 2018·Frontiers in Aging Neuroscience·Jordi A Matias-GuiuMaría Nieves Cabrera-Martín
May 28, 2019·Frontiers in Neurology·Catherine NoriseMurray Grossman
Oct 14, 2017·Alzheimer Disease and Associated Disorders·Hyon LeeYoung Noh
Jan 9, 2021·Journal of Neurology·David FoxeOlivier Piguet
Nov 7, 2020·Brain : a Journal of Neurology·Jeroen van RooijJohn C van Swieten
Feb 18, 2021·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Yat-Fung SheaHon-Wai Felix Chan
Mar 2, 2021·Expert Review of Neurotherapeutics·Cathleen Taylor-RubinLyndsey Nickels
Oct 1, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·David FoxeOlivier Piguet
Jul 27, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·David FoxeOlivier Piguet
Aug 10, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Katheryn A Q CousinsDavid J Irwin
Sep 3, 2021·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Stefania BasilicoGabriella Bottini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.