Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis

World Journal of Gastroenterology : WJG
Yu-Ting ChangJau-Min Wong

Abstract

To investigate how the saturated and unsaturated fatty acid composition influences the susceptibility of developing acute pancreatitis. Primary pancreatic acinar cells were treated with low and high concentrations of different saturated and unsaturated fatty acids, and changes in the cytosolic Ca(2+) signal and the expression of protein kinase C (PKC) were measured after treatment. Unsaturated fatty acids at high concentrations, including oleic acid, linoleic acid, palmitoleic acid, docosahexaenoic acid, and arachidonic acid, induced a persistent rise in cytosolic Ca(2+) concentrations in acinar cells. Unsaturated fatty acids at low concentrations and saturated fatty acids, including palmitic acid, stearic acid, and triglycerides, at low and high concentrations were unable to induce a rise in Ca(2+) concentrations in acinar cells. Unsaturated fatty acids at high concentrations but not saturated fatty acids induced intra-acinar cell trypsin activation and cell damage and increased PKC expression. At sufficiently high concentrations, unsaturated fatty acids were able to induce acinar cells injury and promote the development of pancreatitis. Unsaturated fatty acids may play a distinctive role in the pathogenesis of pancreatitis th...Continue Reading

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Citations

Dec 15, 2016·Frontiers in Physiology·Silvia S Antollini, Francisco J Barrantes
Oct 27, 2017·International Journal of Molecular Sciences·Yoo Kyung Jeong, Hyeyoung Kim
Oct 23, 2018·Experimental and Therapeutic Medicine·Xi CaoZhan-Fei She
Apr 10, 2019·Lipids in Health and Disease·Yanbing DingGuotao Lu
Apr 25, 2020·Frontiers in Medicine·Guillermo García-RayadoEnrique de-Madaria
Feb 6, 2021·Current Atherosclerosis Reports·Jan Pitha, Rudolf Poledne
May 4, 2021·Digestive Diseases and Sciences·Lu WangDong Wu

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