DOI: 10.1101/511543Jan 4, 2019Paper

Distinguishing Closely Related Pancreatic Cancer Subtypes In Vivo by 13C Glucose MRI without Hyperpolarization

BioRxiv : the Preprint Server for Biology
Shun KishimotoMurali C Krishna

Abstract

Metabolic differences between patients and within the tumor itself can be an important determinant in cancer treatment outcome. However, methods for determining these differences non-invasively in vivo have been lacking. Using pancreatic ductal adenocarcinoma as a model, we demonstrate that tumor xenografts with a similar genetic background can be distinguished by their differing rates of metabolism, as imaged by uniformly 13C labeled glucose [U-13C glucose] imaging using a newly developed technique for noise suppression to bring the signal to a detectable level for imaging without hyperpolarization of the tracer. Using this method, cancer subtypes that appeared to exhibit similar metabolic profiles by other techniques that measured steady state metabolism can be distinguished.

Related Concepts

Malignant Neoplasms
Diagnostic Imaging
Glucose
Magnetic Resonance Imaging
Metabolism
Neoplasms
Pancreatic Carcinoma
Subtype (Attribute)
Cancer Treatment
Pancreatic Ductal Adenocarcinoma

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