Distinguishing N-oxide and hydroxyl compounds: impact of heated capillary/heated ion transfer tube in inducing atmospheric pressure ionization source decompositions

Journal of Mass Spectrometry : JMS
Dilrukshi M PeirisRagu Ramanathan

Abstract

In the pharmaceutical industry, a higher attrition rate during the drug discovery process means a lower drug failure rate in the later stages. This translates into shorter drug development time and reduced cost for bringing a drug to market. Over the past few years, analytical strategies based on liquid chromatography/mass spectrometry (LC/MS) have gone through revolutionary changes and presently accommodate most of the needs of the pharmaceutical industry. Among these LC/MS techniques, collision induced dissociation (CID) or tandem mass spectrometry (MS/MS and MS(n)) techniques have been widely used to identify unknown compounds and characterize metabolites. MS/MS methods are generally ineffective for distinguishing isomeric compounds such as metabolites involving oxygenation of carbon or nitrogen atoms. Most recently, atmospheric pressure ionization (API) source decomposition methods have been shown to aid in the mass spectral distinction of isomeric oxygenated (N-oxide vs hydroxyl) products/metabolites. In previous studies, experiments were conducted using mass spectrometers equipped with a heated capillary interface between the mass analyzer and the ionization source. In the present study, we investigated the impact of the ...Continue Reading

Citations

Apr 8, 2011·Journal of the American Society for Mass Spectrometry·Matias ButlerGabriela M Cabrera
Aug 16, 2005·Journal of the American Society for Mass Spectrometry·Thomas PfeiferRegine Fuchs
Apr 7, 2009·Journal of the American Society for Mass Spectrometry·Mingkun FuHilkka I Kenttämaa
Mar 26, 2013·The Science of the Total Environment·Hongxia LiEdward Topp
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Nov 28, 2006·Nuclear Medicine and Biology·Erik SaménSharon Stone-Elander
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