Distinguishing the ORFs from the ELFs: short bacterial genes and the annotation of genomes

Trends in Genetics : TIG
H Ochman

Abstract

A substantial fraction of hypothetical open reading frames (ORFs) in completely sequenced bacterial genomes are short, suggesting that many are not genes but random stretches of DNA. Although it is not feasible to authenticate the coding capacity of all such regions experimentally, comparisons of ORFs in related genomes can expose those that encode functional proteins.

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Jul 17, 2008·Comparative and Functional Genomics·Wagied DavidsSiv G E Andersson
Mar 5, 2003·Trends in Genetics : TIG·Jeffrey Lawrence
Oct 2, 2002·Current Opinion in Microbiology·Alex MiraSiv G E Andersson
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