Distortion in TGF beta 1 peptide immunolocalization in biliary atresia: comparison with the normal pattern in the developing human intrahepatic bile duct system

Pathology International
C E TanH H Cheng

Abstract

Biliary atresia is an important cause of neonatal obstructive jaundice in which there is inflammation, sclerosis and eventual obliteration of the bile duct system. Its onset may be antenatal, affecting the normal development of the biliary system. The intrahepatic biliary system is derived from the ductal plate, a sheath of cuboidal epithelium that appears at the hepatocyte-mesenchymal junction around the portal vein branches at 6 weeks gestation. This epithelial structure is moulded into a network of tubular bile ducts by the proliferating mesenchyme. Certain portions of the ductal plate are selected to become definitive bile ducts, while redundant biliary epithelium is deleted. The molecular dynamics controlling the intra-uterine development of the biliary system in humans are not yet clearly understood. Transforming growth factor-beta 1 is a cytokine that stimulates mesenchymal proliferation and inhibits epithelial growth, and has been shown to be important in organogenesis. In the present study, the pattern of TGF beta 1 peptide immunolocalization was investigated with the aid of computerized image analysis, in normal human bile duct development and in biliary atresia. TGF beta 1 peptide was detected within hepatocytes and ...Continue Reading

References

Jul 1, 1992·Journal of Clinical Gastroenterology·T W Lissoos, B H Davis
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Dec 1, 1987·The Journal of Cell Biology·U HeineM B Sporn
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L BraunN Fausto
May 29, 1987·Biochemical and Biophysical Research Communications·A J StrainR D Milner
Sep 1, 1987·The Journal of Clinical Investigation·R J CoffeyN F LaRusso
Jun 1, 1987·Journal of Pediatric Surgery·J R LillyR H Shikes
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsM B Sporn
Dec 31, 1985·Biochemical and Biophysical Research Communications·T NakamuraA Ichihara
Jan 1, 1985·Journal of Hepatology·V J Desmet
Jan 1, 1971·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·A Koga
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsM B Sporn
Jan 1, 1993·The Journal of Cell Biology·C H StreuliR Derynck

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Citations

Jan 22, 2011·Pediatric Surgery International·Shilpa SharmaDevendra K Gupta
Feb 23, 2007·Molecular Biology of the Cell·Naoki TanimizuKeith E Mostov
Mar 20, 2009·Molecular Biology of the Cell·Naoki TanimizuKeith E Mostov
Feb 12, 1998·The Anatomical Record·V Vijayan, C E Tan
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hsiang-Po HuangMing-Shyue Lee
Apr 15, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Markus MoserReinhard Buettner
Jan 1, 1997·The Tohoku Journal of Experimental Medicine·T TeradaY Nakanuma
Feb 9, 2011·Virchows Archiv : an International Journal of Pathology·Valeer J Desmet
Mar 3, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Ellen Kahn
Mar 2, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naoki TanimizuToshihiro Mitaka
Aug 26, 1998·The American Journal of Pathology·G A RammD H Crawford

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