Distortion of Mendelian recovery ratio for a mouse HSR is caused by maternal and zygotic effects

Genetical Research
D WeichenhanH Winking

Abstract

An HSR in chromosome 1 which is found in many feral populations of Mus musculus domesticus was shown in previous studies to consist of a high-copy long-range repeat cluster. One such cluster, MUT, showed distorted transmission ratios when introduced by female parents. MUT/+ offspring were preferentially recovered at the expense of +/+ embryos in the progeny of male MUT/+ x female +/+ but were found at the expected 1:1 ratio in reciprocal crosses. Preferential recovery of maternal MUT was due to lethality of postimplantation +/+ embryos. There was no distortion of the recovery ratio in MUT/+ x MUT/MUT progeny: maternal MUT and + clusters were present among live implants at a 1:1 ratio. Maternal and zygotic effects therefore contribute to the phenomenon. The mechanism of their interaction is unknown.

References

Jan 24, 1992·Cell·D St Johnston, C Nüsslein-Volhard
Apr 1, 1990·Genetical Research·S I AgulnikA O Ruvinsky
Jan 1, 1988·Annual Review of Genetics·D Solter
Nov 1, 1972·Experimental Cell Research·A T Sumner
Jan 1, 1981·European Journal of Applied Physiology and Occupational Physiology·H A Davis, G C Cass
May 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A Ruvinsky
Apr 1, 1995·Genome Génome / Conseil National De Recherches Canada·D WeichenhanW Traut
Jan 1, 1996·Cytogenetics and Cell Genetics·B KunzeH Winking

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Citations

Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marcé D LorenzenRichard W Beeman
Jun 3, 2014·BMC Evolutionary Biology·Chaitanya S GokhaleFloyd A Reed
Sep 5, 2020·Annual Review of Genetics·Alejandro BurgaLeonid Kruglyak
Jan 12, 2021·ELife·Luke M NobleMatthew V Rockman

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