Distress in relation to attenuated psychotic symptoms in the ultra-high-risk population is not associated with increased risk of psychotic disorder

Early Intervention in Psychiatry
Lucy PowerBarnaby Nelson

Abstract

The 'ultra-high-risk' criteria identify a clinical population at substantially increased risk for progressing to schizophrenia and other psychotic disorders. Although a number of clinical variables predictive of transition to psychotic disorder have been identified within this population, the predictive value of the level of distress associated with attenuated psychotic symptoms has not yet been examined. This was the aim of the present study. The level of distress (0-100) associated with attenuated psychotic symptoms was recorded for 70 ultra-high-risk (UHR) patients using the Comprehensive Assessment of At-Risk Mental State (CAARMS). Transition to psychosis was assessed over a 16-month follow-up period. Of the 70 UHR patients, 15 transitioned to psychosis (21.4%). Of the four CAARMS subscales measuring attenuated positive symptoms, Perceptual Abnormalities was rated as the most distressing. There were no differences in CAARMS scales rated as the most distressing between those who transitioned to psychosis and those who did not. There was also no association between higher levels of distress associated with attenuated psychotic symptoms and transition to psychosis. Although the findings require replication, they indicate that ...Continue Reading

References

Dec 31, 2002·Schizophrenia Research·Alison R YungPatrick D McGorry
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Jul 12, 2005·The British Journal of Clinical Psychology·Manon HanssenJim van Os
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Nov 21, 2012·JAMA Psychiatry·Paolo Fusar-PoliAlison Yung
Jul 12, 2014·Psychopathology·Barnaby Nelson

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Citations

Dec 18, 2019·Psychiatry and Clinical Neurosciences·Natalie SeilerBrian O'Donoghue
Sep 19, 2020·Journal of Psychiatry and Brain Science·Lauren M EllmanVijay A Mittal
Jun 2, 2018·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Patrick D McGorryBarnaby Nelson
Aug 28, 2021·Biomedicines·Paola BozzatelloSilvio Bellino

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